Propranolol


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult: PO Hypertension As conventional tab or oral solution: Initially, 40-80 mg bid, may be increased at weekly intervals according to response. Usual range:160-320 mg daily. Max: 640 mg/day. As extended-release cap: 80 mg once daily. Angina pectoris As conventional tab or oral solution: Initially, 40 mg bid-tid, may be increased according to response. Usual range: 120-240 mg daily. As extended-release cap: 80mg once daily, may be increased to 160 mg once daily. Max: 320 mg. Prophylaxis of migraine As conventional tab or oral solution: Initially, 40 mg bid-tid, may be increased according to response. Usual range: 80-160 mg daily. As extended-release cap: Initially, 80mg once daily, may be increased according to response. Usual effective dose: 160-240 mg once daily. Essential tremor As conventional tab or oral solution: Initially, 40 mg bid-tid, may be increased according to response. Usual range: 80-160 mg daily. As extended-release cap: Initially, 80mg once daily, may be increased according to response. Usual effective dose: 160-240 mg once daily. Cardiac arrhythmias As conventional tab or oral solution: 10-40 mg 3-4 times daily. Myocardial infarction As conventional tab or oral solution: Initiate within 5-21 days of MI, 40 mg 4 times daily for 2-3 days, followed by 80 mg bid. Phaeochromocytoma As conventional tab or oral solution: In combination with an α-blocker: 60 mg daily for 3 days before the surgery. If tumour is unsuitable for surgery, 30 mg/day in divided doses. Hypertrophic cardiomyopathy As conventional tab or oral solution:10-40 mg 3-4 times daily. As extended-release cap: 80-160 mg once daily. Hyperthyroidism As conventional tab or oral solution: 10-40 mg 3-4 times daily. As extended release cap: 80 mg once daily, may be increased to 160 mg daily. Max: 240 mg/day. Anxiety As conventional tab or oral solution: 40 mg daily, may be increased if necessary to 40 mg bid-tid. As extended release cap: 80 mg once daily. Portal hypertension As conventional tab or oral solution: Initially, 40 mg bid, may be increased to 80 mg bid depending on heart rate response. As extended release cap: 80 mg once daily, may be increased to 160 mg once daily. Max: 320 mg once daily. IV Emergency treatment of cardiac arrhythmias 1 mg given over 1 minute, may be repeated if necessary every 2 minutes. Max: 10 mg in conscious patients and 5 mg in patients under anaesthesia.
Administration
Tab: Should be taken on an empty stomach (i.e. At least one hour before food or two hours after food).
Cap: May be taken with or without food. Take consistently either always w/ or always w/o meals.
Contraindications
History of bronchial asthma, bronchospasm chronic obstructive airways disease, bradycardia, cardiogenic shock, hypotension, metabolic acidosis, severe peripheral arterial circulatory disturbances, 2nd or 3rd degree heart block, sick sinus syndrome, untreated pheochromocytoma, uncontrolled heart failure, Prinzmetal's angina.
Special Precautions
Patient with Raynaud's disease or intermittent claudication, 1st degree heart block, diabetes mellitus, myasthenia gravis, psoriasis, thyroid disease. Avoid abrupt withdrawal. Hepatic and renal impairment. Elderly. Pregnancy and lactation. Patient Counselling This drug may cause dizziness, if affected, do not drive or operate machinery. Monitoring Parameters Monitor blood pressure, heart rate,ECG, and serum glucose (in patients with diabetes mellitus).
Adverse Reactions
Blood and lymphatic system disorders: Agranulocytosis, thrombocytopenia. Cardiac disorders: Bradycardia, cardiac failure, AV block. Eye disorders: Visual disturbances, dry eye, conjunctivitis. Gastrointestinal disorders: Nausea, vomiting, diarrhoea, constipation, dry mouth. General disorders and administration site conditions: Lethargy, fatigue. Immune system disorders: Hypersensitivity, anaphylactic reactions. Nervous system disorders: Dizziness. Psychiatric disorders: Hallucination, psychoses, depression, mood changes, confusion, memory loss, sleep disturbances, nightmares. Reproductive system and breast disorders: Impotence, erectile dysfunction. Respiratory, thoracic and mediastinal disorders: Bronchospasm. Skin and subcutaneous tissue disorders: Alopecia, psoriasiform reaction, skin rash. Vascular disorders: Hypotension, cold extremities, Raynaud's phenomenon.
Drug Interactions
May have potentiating effects on arterial conduction time and induce additive negative or inotropic effect with propafenone, amiodarone, quinidine, flecainide and Ca channel blockers. Concomitant administration with catecholamine-depleting drugs (e.g. reserpine), MAOIs or TCAs may cause additive effects and potentiate hypotension. Reduced antihypertensive effect with NSAIDs (e.g. ibuprofen, indometacin). May enhance vasoconstrictive action of ergot alkaloids. Coadministration with warfarin increases its bioavailability and prothrombin time. May enhance hypoglycaemic effects of insulin. Increased risk of hypotension and attenuation of the reflex tachycardia with anaesthetic drugs. Increased plasma concentration with lidocaine.
ATC Classification
C07AA05 - propranolol ; Belongs to the class of non-selective beta-blocking agents. Used in the treatment of cardiovascular diseases.
Disclaimer: This information is independently developed by CIMS based on propranolol from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
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