Protamine sulfate

Generic Medicine Info
Special Precautions
Patient at risk of developing hypersensitivity to protamine (e.g. previous history of procedures such as coronary angioplasty or cardiopulmonary bypass surgery where protamine is frequently used, diabetics using protamine insulin, allergy to fish, vasectomised or infertile males who may have antibodies to protamine). Pregnancy and lactation. Monitoring Parameters Monitor clotting parameters closely esp in prolonged procedures. Monitor aPTT or activated coagulation time, 5-15 min after protamine sulfate admin.
Adverse Reactions
Hypotension, bradycardia, dyspnoea, warm sensation, transient flushing, nausea, vomiting, back pain, lassitude.
Potentially Fatal: Anaphylactoid reactions including circulatory collapse and MI, capillary leak, pulmonary and systemic HTN, angioedema, resp distress syndrome, anaphylaxis. Rarely, noncardiogenic pulmonary oedema w/ prolonged hypotension.
Disclaimer: This information is independently developed by CIMS based on protamine sulfate from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by
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