Rasburicase


Generic Medicine Info
Contraindications
Hypersensitivity. G6PD deficiency, and other cellular metabolic disorders causing haemolytic anaemia.
Special Precautions
Patients with history of atopic allergies. Children. Pregnancy and lactation. Monitoring Parameters Perform G6PD deficiency screening prior to initiation of therapy. Monitor plasma uric acid levels 4 hours after administration then every 6-8 hours until tumour lysis syndrome resolution; CBC. Monitor for signs and symptoms of hypersensitivity reactions.
Adverse Reactions
Significant: Severe haemolytic reactions, methaemoglobinaemia. Gastrointestinal disorders: Diarrhoea, vomiting, nausea, abdominal pain, constipation, mucositis. General disorders and administration site conditions: Fever. Hepatobiliary disorders: Hyperbilirubinemia, increased serum ALT. Infections and infestations: Sepsis. Immune system disorders: IgG and IgE antibody development. Nervous system disorders: Headache. Metabolism and nutrition disorders: Peripheral oedema, hypophosphataemia, hypervolaemia. Psychiatric disorders: Anxiety. Respiratory, thoracic and mediastinal disorders: Pharyngolaryngeal pain.
Potentially Fatal: Serious hypersensitivity reactions (e.g. anaphylactic shock).
ATC Classification
V03AF07 - rasburicase ; Belongs to the class of detoxifying agents used in antineoplastic treatment.
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