Retinol


Full Generic Medicine Info
Dosage/Direction for Use

Oral
Vitamin A deficiency
Adult: For severe deficiency with corneal changes: 500,000 units daily for 3 days, followed by 50,000 units daily for 2 wk and then 10,000-20,000 units daily for 2 mth as follow-up therapy. For cases with corneal changes: 10,000-25,000 units daily until clinical improvement occurs (usually 1-2 wk).
Child: In children with xerophthalmia: 5000 units/kg daily for 5 days or until recovery occurs.

Intramuscular
Patients with biliary cirrhosis or chronic cholestatic liver disease
Adult: 100,000 units every 2-4 mth.

Topical/Cutaneous
Acne
Adult: Apply as cream or ointment on affected areas.

Topical/Cutaneous
Psoriasis
Adult: Apply as cream or ointment on affected areas.
Administration
Should be taken with food.
Contraindications
Hypervitaminosis A; pregnancy (dose exceeding RDA).
Special Precautions
Cholestatic jaundice; fat-malabsorption conditions. Monitor patients closely for toxicity. Liver impairment and children.
Adverse Reactions
Hypervitaminosis A characterised by fatigue, irritability, anorexia, weight loss, vomiting and other GI disturbances, low-grade fever, hepatosplenomegaly, skin changes, alopoecia, dry hair, cracking and bleeding lips, SC swelling, nocturia, pains in bones and joints.
Drug Interactions
Decreased absorption with neomycin. Increased risk of hypervitaminosis A with synthetic retinoids eg, acitretin, isotretinoin and tretinoin. Increased risk of toxicity when used with alcohol.
Action
Retinol (vitamin A) is an essential cofactor in many biological processes for growth, development and maintenance of epithelial tissues and visual adaptation to darkness
Absorption: Well-absorbed from GI tract (except in the presence of fat malabsorption, low-protein intake, impaired hepatic or pancreatic function) after oral administration.
Distribution: Concentrated in the liver. Enters breastmilk.
Metabolism: Hydrolysed to retinol by pancreatic enzymes.
Excretion: Urine and faeces.
ATC Classification
R01AX02 - retinol ; Belongs to the class of other nasal preparations for topical use.
S01XA02 - retinol ; Belongs to the class of other ophthalmologicals.
D10AD02 - retinol ; Belongs to the class of topical retinoid preparations used in the treatment of acne.
Disclaimer: This information is independently developed by CIMS based on retinol from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
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