S-amlodipine + nebivolol

Oral
Hypertension
Adult: 1 cap [S-Amlodipine 2.5mg + Nebivolol 5mg] once daily.

Allergic to dihydropyridine Ca antagonist, hypersensitivity to the active substance or to any of the excipients, liver insufficiency or liver function impairment. Pregnancy, lactation.

History of allergies, psoriasis, hyperthyroidism, peripheral arterial disease, diabetes, elderly.

Headache, fatigue, parasthesias and dizziness, insomnia, nausea, abdominal pain, flushing, pruritus, skin rash, dyspnea, weakness, muscular spasm, and dyspepsia.

S-amlodipine is an enantiomer of amlodipine, which blocks Ca ion outside the cardiac muscle cells and vascular smooth muscle cells via the Ca channel of cytomembrane. It directly dilates vascular smooth muscle, resisting hypertension. The mechanism of remitting angina pectoris is not yet determined completely. It can decrease myocardial ischemia through dilatation of the peripheral small artery, decreasing peripheral resistance, causing the reduction of energy consumption, and O₂ requirement of cardiac muscle and dilating the coronary artery and coronary small artery at normal and ischemic areas, increasing the O₂ supply of the cardiac muscle of the coronary spasm patients.
Nebivolol exerts its actions by exhibiting a high selectivity for beta-1 adrenergic receptors and also by reducing the peripheral vascular resistance by modulating NO release.

Calcium Antagonists / Beta-Blockers

C07AB12 - nebivolol ; Belongs to the class of selective beta-blocking agents. Used in the treatment of cardiovascular diseases.