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Contraindications
Hypersensitivity, thyrotoxicosis.
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Special Precautions
Hepatic impairment, cardiac failure, hypertension, arrhythmias, pulmonary oedema, hyperthyroidism, diabetes mellitus, history of peptic ulcer and convulsive disorders, patients on MAOIs or tricyclic antidepressants, high fever, neonates and infants, pregnancy, lactation.
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Adverse Reactions
Seizures, tremor, muscle cramps, palpitation, hypokalaemia, headache, anorexia, nausea, anxiety, irritability, insomnia, rarely rash and angioedema.
Potentially Fatal: Arrhythmias including premature ventricular contractions. |
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Drug Interactions
Increased theophylline toxicity with propranolol, cimetidine, erythromycin (7-5 days), quinolone antibiotics. Reduced efficacy with rifampicin, phenobarbitone, phenytoin, carbamazepine, sulfinpyrazone and smoking. Increased risk of hypokalaemia with diuretics.
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CIMS Class
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ATC Classification
R03DA04 - theophylline ; Belongs to the class of xanthines. Used in the systemic treatment of obstructive airway diseases.
R03AC02 - salbutamol ; Belongs to the class of adrenergic inhalants, selective beta-2-adrenoreceptor agonists. Used in the treatment of obstructive airway diseases. R03CC02 - salbutamol ; Belongs to the class of adrenergics for systemic use, selective beta-2-adrenoreceptor agonists. Used in the treatment of obstructive airway diseases. |
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