Silver nitrate: Indication, Dosage, Side Effect, Precaution

Concise Prescribing Info Full Prescribing Info

Dosage/Direction for Use Contraindications Special Precautions Adverse Reactions Action CIMS Class ATC Classification

Full Prescribing Info

Dosage/Direction for Use

Topical/Cutaneous
Prophylaxis of gonococcal ophthalmia neonatorum
Child: Neonate: As a 1% solution: To be applied after cleansing of the neonate's eyes immediately after birth.

Topical/Cutaneous
As an antiseptic agent
Adult: As a 0.5% solution: May be applied to severe burns to reduce risk of infection.

Contraindications

Hypersensitivity. Applicator sticks not for ophthalmic use.

Special Precautions

Prolonged use may result to skin discolouration. Protect surrounding skin and avoid broken skin. Not suitable for application to face, ano-genital region or large areas.

Adverse Reactions

Pain in the mouth, sialorrhoea, diarrhoea, vomiting, coma and convulsions. Argyria (chronic use); methaemoglobinaemia; electrolyte disturbances. Short-term mild conjunctivitis in infants which may lead to blindness if use repeatedly or with high concentrations.

Action

Silver nitrate inhibits growth of both gram-positive and gram-negative bacteria by precipitating bacterial protein through the release of liberated silver ions. It also forms an eschar by coagulation of cellular proteins.
Absorption: Minimal GI and cutaneous absorption because of the readiness of silver ions to combine with protein.
Excretion:

CIMS Class

Skin Antiseptics & Disinfectants

ATC Classification

D08AL01 - silver nitrate ; Belongs to the class of silver compound antiseptics. Used in the treatment of dermatological diseases.

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