Sodium bicarbonate

Concise Prescribing Info
Listed in Dosage.
Dosage/Direction for Use
Adult: PO Dyspepsia 1-5 g 4-6 hourly as necessary. Alternatively, 0.65-2.6 g 4 hourly. Metabolic acidosis Dosage calculation is individualised according to acid-base balance and electrolyte status of the patient. IV Metabolic acidosis Severe cases: Usual dose: 1 mmol/kg (1 mL/kg of 8.4% Na bicarbonate solution) via inj, followed by 0.5 mmol/kg given at 10-minute intervals depending on individual arterial blood gases. Less urgent cases: 2-5 mmol/kg given via infusion over 4-8 hours based on the severity of acidosis as judged by the decrease of total CO2 content, blood pH, and clinical condition of patient. Dosage recommendations may vary in the country of use (refer to local treatment protocol and guidelines).
Should be taken on an empty stomach (i.e. At least one hour before food or two hours after food).
Metabolic or respiratory alkalosis, hypocalcaemia, hypochlorhydria, severe pulmonary oedema, unknown abdominal pain. IV: Conditions with Na intake restrictions (e.g. renal failure), hypoventilation, history of urinary calculi, coexisting K depletion, hypernatraemia. Patient with chloride loss due to vomiting or continuous gastrointestinal suction. IV: Concomitant use with diuretics known to produce hypochloraemic alkalosis.
Special Precautions
Patient with CHF, hypertension, cirrhosis, on low Na diet; eclampsia, oedema, aldosteronism or other conditions associated with Na retention; oliguria or anuria. Avoid extravasation (IV). Renal and hepatic impairment. Children. Pregnancy and lactation. Monitoring Parameters Monitor serum electrolytes, including serum Ca; urinary pH, arterial blood gases if necessary. IV: Perform arterial blood gas analyses, especially arterial/venous blood pH and CO2 levels, prior to and during the treatment course. Monitor cardiac status, infusion site, and for signs of fluid retention.
Adverse Reactions
Significant: Metabolic alkalosis, hypernatraemia; fluid and/or solute overload (IV); tissue necrosis, vascular irritation or sloughing (IV extravasation); decreased CSF pressure and intracranial haemorrhage (rapid IV inj in neonates). Gastrointestinal disorders: Abdominal pain, flatulence, spontaneous stomach rupture, nausea, vomiting, unpleasant taste. General disorders and administration site conditions: Unusual tiredness or weakness. Metabolism and nutrition disorders: Fluid retention, hypocalcaemia, exacerbated hypokalaemia, loss of appetite. Musculoskeletal and connective tissue disorders: Muscle spasms or cramps. Nervous system disorders: Headache, restlessness. Psychiatric disorders: Mood or mental changes, nervousness, extreme irritability. Renal and urinary disorders: Frequent urge to urinate. Respiratory, thoracic and mediastinal disorders: Pulmonary oedema, breathing difficulty, fluid in the lungs. Vascular disorders: Hypertension.
Drug Interactions
Increased excretion of lithium, aspirin, methotrexate. Reduced excretion of quinidine, amphetamines, methadone, quinine, and ephedrine. Reduced absorption of tetracycline, rifampicin, ketoconazole, dipyridamole, chloroquine, phenothiazines, phenytoin, penicillamine. May increase the renal tubular reabsorption of mecamylamine. May reduce the serum K concentration with K supplements.
ATC Classification
B05XA02 - sodium bicarbonate ; Belongs to the class of electrolyte solutions used in I.V. solutions.
B05CB04 - sodium bicarbonate ; Belongs to the class of salt solutions used as irrigating solutions.
Disclaimer: This information is independently developed by CIMS based on sodium bicarbonate from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 CIMS. All rights reserved. Powered by
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