Sultamicillin


Generic Medicine Info
Contraindications
Hypersensitivity to ampicillin, sulbactam, or penicillins.
Special Precautions
Renal impairment. Children. Pregnancy and lactation. Monitoring Parameters Monitor for signs of anaphylaxis during 1st dose. Monitor haematologic, renal, and hepatic function periodically during prolonged use. May perform culture and susceptibility tests prior to treatment initiation; consult local institutional recommendations before treatment initiation due to antibiotic resistance risks.
Adverse Reactions
Significant: Severe skin reactions (e.g. Stevens-Johnson syndrome, toxic epidermal necrolysis, dermatitis exfoliative, erythema multiforme, acute exanthematous pustulosis); cholestatic hepatitis, jaundice; fungal or bacterial superinfection including Clostridium difficile-associated diarrhoea (CDAD) and pseudomembranous colitis (prolonged use). Gastrointestinal disorders: Diarrhoea, nausea, vomiting, abdominal pain, melaena, stomatitis. General disorders and administration site conditions: Fatigue, malaise. Infections and infestations: Candida infection. Investigations: Decreased plasma concentration of total conjugated estriol, estriol glucuronide, conjugated estrone, and estradiol (in pregnant women). Musculoskeletal and connective tissue disorders: Arthralgia. Nervous system disorders: Headache, dizziness. Skin and subcutaneous tissue disorders: Pruritus, rash.
Potentially Fatal: Hypersensitivity reactions (e.g. anaphylaxis).
Drug Interactions
Increased incidence of rashes with allopurinol. May enhance the effect of anticoagulants. Bacteriostatic drugs (e.g. chloramphenicol, erythromycin, sulfonamides, tetracyclines) may interfere with the bactericidal effect of sultamicillin. Diminished therapeutic efficacy of estrogen-containing oral contraceptives. Decreased clearance of methotrexate thus increase toxicity. Increased and prolonged serum concentrations with probenecid.
CIMS Class
Penicillins
Disclaimer: This information is independently developed by CIMS based on sultamicillin from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
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