Generic Medicine Info
Should be taken on an empty stomach. Take on an empty stomach 1 hr before or 2 hr after meals.
Hypersensitivity to tacrine or acridine derivatives. History of jaundice with tacrine therapy. Lactation.
Special Precautions
Monitor serum-alanine aminotransferase concentration. Avoid abrupt withdrawal or large dose reduction. Impaired liver function or history of liver function abnormalities, epilepsy, bronchial asthma, bradycardia, CV conduction disorders, GI or urinary tract obstruction, recent intestinal or bladder surgery, risk of peptic ulcer. Pregnancy. Smoking may reduce serum tacrine levels.
Adverse Reactions
Dizziness, headache, nausea, vomiting, diarrhoea, myalgia, ataxia.
Potentially Fatal: Hepatotoxicity.
Drug Interactions
Increased serum tacrine levels with coadmin of cimetidine, fluvoxamine, quinolones and HRT. Increased theophylline levels with concurrent tacrine use. Increased cholinergic side effects with other cholinergic agents, cholinesterase inhibitors, and succinylcholine. Antagonise effects of anticholinergic drugs. Increased risk of bradycardia with β-blockers and calcium channel blockers.
ATC Classification
N06DA01 - tacrine ; Belongs to the class of anticholinesterases. Used in the management of dementia.
Disclaimer: This information is independently developed by CIMS based on tacrine from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
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