Telmisartan


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult: PO Hypertension Initial: 40 mg once daily, may be adjusted to 20-80 mg once daily according to clinical response. Max: 80/day. CV risk reduction 80 mg once daily.
Administration
May be taken with or without food.
Contraindications
Biliary obstructive disorders. Concomitant use with aliskiren in patient with diabetes mellitus or renal impairment (GFR<60 mL/min/1.73 m2). Severe hepatic impairment. Pregnancy.
Special Precautions
Patient with aortic or mitral stenosis, obstructive hypertrophic cardiomyopathy, ischaemic cardiopathy, unstented unilateral or bilateral renal artery stenosis; ascites due to cirrhosis, refractory ascites, Patients undergoing major surgery or during anaesthesia. Black race. Mild to moderate hepatic and renal impairment. Lactation. Patient Counselling This drug may cause dizziness or drowsiness, if affected, do not drive or operate machinery. Monitoring Parameters Monitor blood pressure regularly; serum creatinine, electrolyte levels e.g. serum K, and BUN. Assess pregnancy status and signs of angioedema.
Adverse Reactions
Significant: Hypotension, orthostatic hypotension, bradycardia, angina pectoris, tachycardia, hypertension, peripheral oedema, intermittent claudication, increased serum creatinine. Rarely, hypoglycaemia, interstitial lung disease. Blood and lymphatic system disorders: Anaemia, eosinophilia, thrombocytopenia. Cardiac disorders: Chest pain, palpitation, dyspnoea. Ear and labyrinth disorders: Tinnitus, vertigo. Eye disorders: Visual disturbance, conjunctivitis. Gastrointestinal disorders: Diarrhoea, abdominal pain, dyspepsia, flatulence, nausea, vomiting. General disorders and administration site conditions: Fatigue, asthenia, influenza-like illness. Hepatobiliary disorders: Abnormal hepatic function. Investigations: Elevated serum uric acid, increased blood creatine phosphokinase. Musculoskeletal and connective tissue disorders: Back pain, myalgia, arthralgia. Nervous system disorders: Dizziness, headache, somnolence. Psychiatric disorders: Insomnia, depression, anxiety. Renal and urinary disorders: UTI, cystitis. Respiratory, thoracic and mediastinal disorders: Upper respiratory tract infection, sinusitis, pharyngitis, cough. Skin and subcutaneous tissue disorders: Rash, pruritus, hyperhidrosis, dermatitis. Vascular disorders: Syncope, flushing.
Potentially Fatal: Hyperkalaemia, renal function deterioration characterised by oliguria, progressive azotaemia, and acute renal failure. Rarely, angioedema, toxic skin eruption, sepsis.
Drug Interactions
Increased risk of hypotension with high doses of diuretics (e.g. furosemide, hydrochlorothiazide) and other antihypertensives. May elevate plasma concentrations of digoxin. Increased risk of hyperkalaemia with K-sparing diuretics (e.g. spironolactone, eplerenone, triamterene, amiloride), K supplements or K-containing salt substitutes; ACE inhibitors, heparin, immunosuppressants (e.g. ciclosporin, tacrolimus), trimethoprim. May reduce antihypertensive effect and deteriorate renal function with aspirin, NSAIDs including selective COX-2 inhibitors. May increase serum lithium levels and toxicity. Decreased antihypertensive effect with systemic corticosteroids.
ATC Classification
C09CA07 - telmisartan ; Belongs to the class of angiotensin II antagonists. Used in the treatment of cardiovascular disease.
Disclaimer: This information is independently developed by CIMS based on telmisartan from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 CIMS. All rights reserved. Powered by CIMSAsia.com
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