Thiamphenicol


Full Generic Medicine Info
Dosage/Direction for Use

Oral
Sexually transmitted diseases
Adult: 1.5 g daily in divided doses, up to 3 g/day initially for severe infections.
Child: 30-100 mg/kg/day.
Renal impairment:
CrCl (ml/min)Dosage Recommendation
30-60500mg bid.
10-30500mg once daily.


Oral
Susceptible infections
Adult: 1.5 g daily in divided doses, up to 3 g/day initially for severe infections.
Child: 30-100 mg/kg/day.
Renal impairment:
CrCl (ml/min)Dosage Recommendation
30-60500mg bid.
10-30500mg once daily.


Oral
Gonorrhoea
Adult: 2.5 g/day for 1-2 days. Alternatively, 2.5 g on the 1st day followed by 2 g/day on each of 4 subsequent days.
Renal impairment:
CrCl (ml/min)Dosage Recommendation
30-60500mg bid
10-30500mg once daily.
Contraindications
Hypersensitivity, preexisting bone marrow depression or blood dyscrasias, active immunisation. Pregnancy and lactation.
Special Precautions
Renal impairment, Mediterranean form of G6PD, prolonged use. Perform routine periodic blood examination.
Adverse Reactions
Hypersensitivity, GI disturbances, stomatitis, glossitis, encephalopathy, mental depression and headache, ototoxicity. Haemolytic anaemia (Mediterranean form of G6PD), Jarish-Herxheimer reaction. Prolonged use may induce bleeding, peripheral and optic neuritis.
Potentially Fatal: Bone marrow depression; grey baby syndrome, anaphylactic reactions.
Action
Thiamphenicol has a broad spectrum of activity similar to chloramphenicol. It is less active than chloramphenicol but it is equally effective and more actively bactericidal against Haemophilus and Neisseria spp. It reversibly binds to 50s subunit of bacterial ribosome blocking the transpeptidation and inhibiting protein synthesis of susceptible bacteria, thus inhibiting cell growth.
Absorption: Peak serum concentrations: 2 hr.
Distribution: Diffuses into the CSF, across the placenta, into breast milk and into the lungs. Protein binding: 10%. Half-life: 2-3 hr, increased in renal impairment.
Metabolism: Undergoes little or no conjugation with glucuronic acid in the liver.
Excretion: Excreted in the urine mainly as unchanged drug (70%); small amount excreted in bile and faeces.
CIMS Class
Chloramphenicols
ATC Classification
J01BA02 - thiamphenicol ; Belongs to the class of amphenicols. Used in the systemic treatment of infections.
Disclaimer: This information is independently developed by CIMS based on thiamphenicol from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
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