Triamcinolone


Generic Medicine Info
Administration
Should be taken with food.
Contraindications
Hypersensitivity. Acute psychoses, active TB, herpes simplex keratitis, systemic mycoses, parasitosis (Strongyloides infections).
Special Precautions
Patient with cardiac insufficiency, acute CAD, hypertension, recent MI, thrombophlebitis, thromboembolism, diabetes mellitus, myasthenia gravis, Cushing's syndrome, hypothyroidism, osteoporosis, exanthematous diseases, psychosis; gastrointestinal diseases (e.g. diverticulosis, diverticulitis, active or latent peptic ulcer, ulcerative colitis, fresh intestinal anastomoses, pyogenic infection); cataracts, glaucoma, history of ocular herpes simplex; seizure disorder, systemic sclerosis, acute glomerulonephritis, chronic nephritis, cirrhosis, infections untreatable with antibiotics, metastatic carcinoma. Not for intra-articular administration during active infection or near joints. Not for use to alleviate joint pain associated with infectious states (e.g. gonococcal or tubercular arthritis). Patient subject to stress (e.g. trauma, surgery, severe infection). Avoid exposure to chickenpox or measles. Avoid abrupt withdrawal. Children and elderly. Renal and hepatic impairment. Pregnancy and lactation. Monitoring Parameters Monitor weight, blood pressure, blood glucose, electrolytes, IOP, BMD; growth and development in children, HPA axis suppression.
Adverse Reactions
Significant: Hypercortisolism or suppression of HPA axis (prolonged use); immunosuppression (e.g. secondary infections, activation of latent infection, mask acute infections); Kaposi sarcoma (prolonged use); acute myopathy (high doses); psychiatric disturbances (e.g. insomnia, mood swings, euphoria, personality changes, severe depression, frank psychotic manifestations; exacerbation of pre-existing psychiatric conditions; septic arthritis; fluid retention, electrolyte disturbance, hypertension, myocardial rupture; hyperglycaemia; worsening of myasthenia gravis; increased IOP, open-angle glaucoma, cataracts (prolonged use); increased bone loss, osteoporotic fractures; scleroderma renal crisis; menstrual irregularities; vaginal bleeding (particularly in postmenopausal women). Rarely, anaphylactoid reactions. Ear and labyrinth disorders: Rarely, vertigo. General disorders and administration site conditions: Sterile abscess, post-inj erythema; pain, swelling, and necrosis at the inj site. Skin and subcutaneous tissue disorders: Rarely, hyper- or hypo-pigmentation. Vascular disorders: Rarely, thromboembolism.
Potentially Fatal: Strongyloides hyperinfection and dissemination; serious anaphylactoid reactions.
ROUTE(S) : IB / Intradermal / Intrasynovial / SC / Topical / Intra-articular / Intralesional / IM / Parenteral: C
ROUTE(S) : Intravitreal: D
Drug Interactions
Increased risk of additive hypokalaemia with Amphotericin B inj and K-depleting agents. Increased risk of acute myopathy with neuromuscular blocking agents. May inhibit the effect of anticholinesterases. Additional increase of IOP with anticholinergics (e.g. atropine). May increase or diminish the therapeutic effect of oral anticoagulants. May diminish the therapeutic effect of antidiabetics (e.g. sulfonylurea derivatives) and insulin. May diminish therapeutic effect of antihypertensive agents, including diuretics. Increase in both ciclosporin and corticosteroids activity when used concomitantly. May decrease serum concentration of isoniazid. May increase the risk of digitalis toxicity. Increased clearance with hepatic enzyme inducers (e.g. barbiturates, phenytoin, carbamazepine, rifampicin, primidone, and aminoglutethimide). May decrease clearance and increase the risk of Cushing's syndrome and adrenal suppression with CYP3A4 inhibitors (e.g. ritonavir) including cobicistat-containing products. May decrease therapeutic effect of somatropin. Increased risk and severity of gastrointestinal bleeding and ulceration associated with NSAIDs. May decrease serum salicylate levels. Increased serum levels with oestrogen (including oral contraceptives). Neurological complications and diminished antibody response with live vaccines.
CIMS Class
Corticosteroid Hormones
ATC Classification
R03BA06 - triamcinolone ; Belongs to the class of other inhalants used in the treatment of obstructive airway diseases, glucocorticoids.
H02AB08 - triamcinolone ; Belongs to the class of glucocorticoids. Used in systemic corticosteroid preparations.
R01AD11 - triamcinolone ; Belongs to the class of topical corticosteroids used for prophylaxis and treatment of allergic rhinitis.
D07XB02 - triamcinolone ; Belongs to the class of moderately potent (group II) corticosteroids in other combinations. Used in the treatment of dermatological diseases.
C05AA12 - triamcinolone ; Belongs to the class of products containing corticosteroids for topical use. Used in the treatment of hemorrhoids and anal fissures.
A01AC01 - triamcinolone ; Belongs to the class of local corticosteroid preparations. Used in the treatment of diseases of the mouth.
D07AB09 - triamcinolone ; Belongs to the class of moderately potent (group II) corticosteroids. Used in the treatment of dermatological diseases.
S01BA05 - triamcinolone ; Belongs to the class of corticosteroids. Used in the treatment of inflammation of the eye.
Disclaimer: This information is independently developed by CIMS based on triamcinolone from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2024 CIMS. All rights reserved. Powered by CIMSAsia.com
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Already a member? Sign in
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Already a member? Sign in