Vardenafil


Generic Medicine Info
Administration
May be taken with or without food.
Contraindications
Severe CV disorder or recent history of stroke or MI (within the last 6 months), unstable angina, retinitis pigmentosa, vision loss due to non-arteritic anterior ischaemic optic neuropathy (NAION), ESRD requiring dialysis, hypotension <90/50 mmHg, and other conditions wherein sexual intercourse is inadvisable. Severe hepatic impairment (Child-Pugh class C). Concomitant use with any form of organic nitrates/nitrites, guanylate cyclase stimulators.
Special Precautions
Patient with CV disease, left ventricular outflow obstruction (aortic stenosis or hypertrophic obstructive cardiomyopathy), anatomical penile deformation, conditions which may predispose to priapism (e.g. sickle cell anaemia, multiple myeloma, leukaemia); bleeding disorders, peptic ulcer disease. Severe renal and mild to moderate hepatic impairment. Elderly. Pregnancy and lactation. Patient Counselling This medicine may cause dizziness and blurred vision, if affected, do not drive or operate machinery. Monitoring Parameters Assess CV status prior to initiation of therapy. Monitor BP, heart rate, renal function, and LFT.
Adverse Reactions
Significant: Hypotension, color discrimination impairment, vision loss/NAION, sudden decrease or loss of hearing, tinnitus. Rarely, prolonged/painful erection or priapism. Gastrointestinal disorders: Dyspepsia, nausea. General disorders and administration site conditions: Flu-like symptoms. Nervous system disorders: Headache, dizziness. Respiratory, thoracic and mediastinal disorders: Nasal congestion, sinusitis.
Drug Interactions
May enhance hypotensive effect of α-blockers. Increased serum concentration with guanylate cyclase stimulators (e.g. riociguat), potent CYP3A4 inhibitors (e.g. ketoconazole) and moderate CYP3A4 inhibitors (e.g. clarithromycin), HIV protease inhibitors (e.g. ritonavir). May prolong Qt interval with class IA (e.g. quinidine, procainamide) or class III (e.g. amiodarone, sotalol) antiarrhythmics.
CIMS Class
Drugs for Erectile Dysfunction
ATC Classification
G04BE09 - vardenafil ; Belongs to the class of drugs used in erectile dysfunction.
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