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Indications/Uses
Passive immunisation against varicella infections.
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Dosage/Direction for Use
Adult: IM Dosing is based on patient's wt. ≤10 kg: 125 u; 10.1-20 kg: 250 u; 20.1-30 kg: 375 u; 30.1-40 kg: 500 u; >40 kg: 625 u. To be given as a single deep inj; if the vol to be injected is >5 mL, dose should be divided and administered at different sites. May repeat dose at 3-wk intervals if patient is re-exposed or continuously exposed to varicella until the risk of exposure is no longer present. Dose should preferably be given w/in 48 hr but no later than 96 hr after exposure.
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Contraindications
History of hypersensitivity to immune globulins. IM admin should not be used in patients with severe thrombocytopenia or coagulation disorders.
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Special Precautions
Caution when used in patients with a specific IgA deficiency due to possible presence of antibodies to IgA. Risk of transmitting infectious agents thus vaccination should be considered where appropriate. Caution when used in pregnant and lactating women.
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Adverse Reactions
Inj site reactions e.g. local erythema, redness and pain. GI symptoms, malaise, headache, rash and respiratory symptoms. Chest pain, dyspnoea, tremor, dizziness, glossitis, buccal ulceration, facial oedema, arthralgia.
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Drug Interactions
Concurrent use may interfere with the immune response to certain live vaccines.
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CIMS Class
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