Abbotic/Abbotic Granule/Abbotic XL

Abbotic/Abbotic Granule/Abbotic XL

clarithromycin

Manufacturer:

Abbott Products
Concise Prescribing Info
Contents
Clarithromycin
Indications/Uses
Upper & lower resp tract infections, pharyngitis/tonsillitis, acute maxillary sinusitis, acute otitis media, uncomplicated skin & skin structure infections; disseminated mycobacterial infections. Eradication of H. pylori.
Dosage/Direction for Use
FC tab Usual recommended dose: 250 mg twice daily, may be increased to 500 mg twice daily for severe infections. Duration of therapy: 7-14 days. Patient w/ renal impairment (CrCl <30 mL/min) Dose reduced by ½ & not to be continued beyond 14 days. Haemolytic streptococcal infection Administered at least 10 days. Dry syr Childn 7.5 mg/kg twice daily for 5-10 days. Dose may be increased to a max of 500 mg for severe infections. Streptococcal pharyngitis Childn 30-40 kg 2 mL, 20-29 kg 1.5 mL, 12-19 kg 1 mL, 8-11 kg 0.5 mL. MR tab 500-1,000 mg once daily for 7-14 days. Abbotic XL Adult 500 mg once daily. May be increased to 1,000 mg once daily.
Administration
Should be taken with food: Swallow whole, do not chew/crush. 
Contraindications
Hypersensitivity to macrolide antibiotic drugs. Patients receiving terfenadine therapy who have preexisting cardiac abnormalities or electrolyte disturbances. Avoid co-administration w/ cisapride, pimozide, terfenadine & astemizole. Abbotic XL Patients w/ CrCl <30 mL/min.
Special Precautions
Pseudomembraneous colitis, antibiotic-associated colitis. Hepatic or moderate to severe renal impairment. Consider management w/ fluids, electrolytes, protein supplementation. Discontinue clarithromycin if superinfection occurs. Attention to the possibility of cross resistance w/ other macrolide drugs, as well as lincomycin & clindamycin. Pregnancy & lactation. Childn <6 mth. Elderly.
Adverse Reactions
GI-related complaints; headache, altered taste & transient elevations of liver enzymes. Increased serum creatinine, glutaryl transferase. Allergic reactions. Transient CNS side effects. Reversible hearing loss; glossitis, stomatitis, oral monillia, tongue discoloration & reversible tooth discoloration. Hypoglycemia. Thrombocytopenia. Hepatic dysfunction.
Drug Interactions
Theophylline, carbamazepine, drugs metabolized by the CYP450, terfenadine, astemizole, zidovudine, dideoxyinosine, digoxin.
MIMS Class
ATC Classification
J01FA09 - clarithromycin ; Belongs to the class of macrolides. Used in the systemic treatment of infections.
Presentation/Packing
Form
Abbotic Granule dry syr 125 mg/5 mL
Packing/Price
30 mL x 1's (Rp64,570/botol);60 mL x 1's (Rp114,455/botol)
/indonesia/image/info/abbotic granule dry syr 125 mg-5 ml/125 mg-5 ml x 30 ml?id=078cfcd8-e75a-42d6-92bf-9fab01882606
/indonesia/image/info/abbotic granule dry syr 125 mg-5 ml/125 mg-5 ml x 60 ml?id=ff10c709-258c-47f8-b33e-9fab018825d3
Form
Abbotic Granule dry syr 250 mg/5 mL
Packing/Price
50 mL x 1's
Form
Abbotic FC tab 500 mg
Packing/Price
3 × 10's (Rp718,355/boks)
Form
Abbotic XL MR tab 500 mg
Packing/Price
5 × 2's (Rp285,120/boks)
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