Amitiza

Amitiza

lubiprostone

Manufacturer:

Takeda
Concise Prescribing Info
Contents
Lubiprostone
Indications/Uses
Chronic idiopathic constipation in adults. Irritable bowel syndrome w/ constipation in women ≥18 yr.
Dosage/Direction for Use
Chronic idiopathic constipation 24 mcg twice daily until 28 days. Moderate hepatic impairment (Child-Pugh Class B) 16 mcg twice daily. Severe hepatic impairment (Child-Pugh Class C) 8 mcg twice daily. Irritable bowel syndrome w/ constipation 8 mcg twice daily until 12 wk. Severe hepatic impairment (Child-Pugh Class C) 8 mcg once daily.
Administration
Should be taken with food: Swallow whole, do not chew/break.
Contraindications
Hypersensitivity. Patients w/ known or suspected mechanical GI obstruction.
Special Precautions
Nausea. Discontinue use if severe diarrhea occurs. Risk of syncope & hypotension during treatment. Concomitant use of BP-lowering medication; diarrhea or vomiting may increase risk of syncope & hypotension. Dyspnea. Perform thorough evaluation to confirm absence of obstruction prior to initiating therapy in patients w/ symptoms of mechanical GI obstruction. Not to be taken by patients w/ rare hereditary problems of fructose intolerance. Patients w/ moderate (Child-Pugh Class B) & severe hepatic impairment (Child-Pugh Class C). Pregnancy. Monitor infants of nursing mothers for diarrhea. Childn <6 yr.
Adverse Reactions
Nausea, diarrhea, headache, abdominal pain, distension & flatulence.
Drug Interactions
Decreased efficacy may occur w/ diphenylheptane opioids (eg, methadone).
ATC Classification
A06AX03 - lubiprostone ; Belongs to the class of other laxatives.
Presentation/Packing
Form
Amitiza soft-gelatin cap 8 mcg
Packing/Price
6 × 10's (Rp900,000/boks)
Form
Amitiza soft-gelatin cap 24 mcg
Packing/Price
6 × 10's (Rp1,080,000/boks)
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