Aromasin

Aromasin

exemestane

Manufacturer:

Pfizer
Concise Prescribing Info
Contents
Exemestane
Indications/Uses
Advanced breast cancer in women w/ natural or induced postmenopausal status whose disease has progressed following antiestrogen therapy. Patient selection should be based on positive oestrogen &/or progesterone receptor status, because efficacy has not been demonstrated when it is absent. Adjuvant treatment of postmenopausal women w/ estrogen-receptor positive early breast cancer, following 2-3 yr of initial adjuvant tamoxifen therapy.
Dosage/Direction for Use
Adult & elderly 25 mg once daily. Patient w/ early breast cancer Continue until completion of 5 yr of adjuvant endocrine therapy or until local or distant recurrence or new contralateral breast cancer. Patient w/ advanced breast cancer Continue until tumor progression is evident.
Administration
Should be taken with food.
Contraindications
Hypersensitivity. Pre-menopausal women. Pregnancy & lactation.
Special Precautions
Not for women w/ premenopausal endocrine status. Postmenopausal status ascertained by assessment of LH, FSH & oestradiol levels. Assess bone mineral density in women w/ osteoporosis or at risk of osteoporosis. Reduction of bone mineral density. Consider routine assessment of 25 hydroxy vit D levels prior to start of aromatase inhibitor treatment. Supplementation of vit D in women w/ vit D deficiency. Hepatic or renal impairment. May impair ability to drive or operate machinery. Childn.
Adverse Reactions
Hot flushes; depression, insomnia; headache, dizziness; abdominal pain, nausea; increased hepatic enzyme, blood bilirubin, blood alkaline phosphatase; increased sweating; joint & musculoskeletal pain; pain, fatigue. Anorexia; carpal tunnel syndrome; vomiting, diarrhoea, constipation, dyspepsia; alopecia, rash; fracture, osteoporosis; peripheral oedema, asthenia. Paraesthesia, urticaria, pruritus.
Drug Interactions
May negate the pharmacological action w/ oestrogen-containing medicines. May reduce efficacy w/ rifampicin, anticonvulsants (eg, phenytoin & carbamazepine) & St. John's wort.
ATC Classification
L02BG06 - exemestane ; Belongs to the class of enzyme inhibitors. Used in treatment of neoplastic diseases.
Presentation/Packing
Form
Aromasin sugar-coated tab 25 mg
Packing/Price
2 × 15's (Rp2,010,723/boks)
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