Benzbromarone


Concise Prescribing Info
Indications/Uses
Hyperuricemia.
Dosage/Direction for Use
Adult : PO 50-200 mg/day.
Dosage Details
Oral
Hyperuricaemia with gout
Adult: 50-200 mg daily.
Administration
Should be taken with food.
Contraindications
Severe or moderate renal impairment. Patients with uric acid renal calculi, urinary uric acid excretion rates >700 mg/24 hr.
Special Precautions
May exacerbate and prolong acute gout; start treatment only after acute attack has subsided. Adequate fluid intake should be maintained. Monitor liver function.
Adverse Reactions
GI effects; acute attack of gout, uric acid renal calculi, renal colic. May cause liver damage.
Drug Interactions
Efficacy may be antagonised when used with aspirin and other salicylates. May increase the activity of coumarin oral anticoagulants.
Action
Description: Benzbromarone reduces plasma concentrations of uric acid by blocking renal tubular reabsorption and possibly by increasing intestinal elimination of uric acid.
Pharmacokinetics:
Absorption: Partially absorbed from the GI tract.
Distribution: Extensively bound to plasma proteins.
Metabolism: Metabolised in the liver.
Excretion: Mainly excreted in the faeces, a small amount appears in the urine.
Disclaimer: This information is independently developed by MIMS based on Benzbromarone from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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