Adult: For preparation of diagnostic procedures and in pre- and postoperative treatment: 10 mg for 2 doses given in the morning and evening, followed by 10 mg rectal supp/enema on the following morning. Child: >4-10 years 5 mg in the evening followed by 5 mg rectal supp on the following morning; >10 years Same as adult dose.
Adult: 5-10 mg once daily before bedtime. Max: 20 mg. Child: >4-10 years 5 mg once daily before bedtime; >10 years Same as adult dose.
Adult: As supp or enema: 10 mg daily preferably in the morning. Child: >4-10 years As supp: 5 mg daily preferably in the morning; >10 years Same as adult dose.
Should be taken on an empty stomach. Do not take w/in 1 hr of antacids, milk or other dairy products.
Severe dehydration, ileus, intestinal obstruction, acute abdominal conditions (e.g. appendicitis, acute inflammatory bowel disease, severe abdominal pain). Rectal: Anal fissures, proctitis or ulcerated haemorrhoids.
Patient with inflammatory bowel disease. Renal impairment. Children. Pregnancy and lactation. Avoid prolonged use (>5 days).
Significant: Fluid and electrolyte imbalance e.g. metabolic acidosis or alkalosis, hypocalcaemia, hypokalaemia (prolonged use). Gastrointestinal disorders: Abdominal pain, bloody diarrhoea, nausea, abdominal cramps, haematochezia, vomiting, abdominal discomfort, anorectal discomfort, rectal burning (suppository). Rarely, colitis. Metabolism and nutrition disorders: Rarely, dehydration. Nervous system disorders: Dizziness.
This drug may cause dizziness or syncope, if affected, do not drive or operate machinery.
Symptoms: Watery stools, abdominal cramps, fluid and electrolytes loss. Chronic case: Chronic diarrhoea, abdominal pain, hypokalaemia, secondary hyperaldosteronism, renal calculi, renal tubular damage, metabolic alkalosis, muscle weakness. Management: Perform gastric lavage or induce vomiting to minimise absorption. Fluid replacement and correction of electrolyte imbalance may be required.
High dose of bisacodyl may increase the risk of electrolyte imbalance with concomitant use of diuretics or adrenocorticosteroids. Enhanced gastrointestinal adverse effects with concomitant use of other laxatives. Decreased therapeutic effect and increased risk of dyspepsia and gastric irritation with antacids.
Increased risk of dyspepsia and gastric irritation with milk products.
Description: Bisacodyl, a diphenylmethane derivative, directly irritates the smooth muscle of the intestine, possibly the colonic intramural plexus, thereby stimulating peristalsis. It alters water and electrolyte secretion, producing net intestinal fluid accumulation and stimulates defaecation. Onset: Laxative effect: 6-12 hours (oral); within 15-60 minutes (suppository); within 5-20 minutes (enema). Pharmacokinetics: Absorption: Systemic absorption: <5%. Distribution: Volume of distribution: 289 L (active metabolite). Metabolism: Metabolised in the colon to active metabolite, bis-(-p-hydroxyphenyl)-pydidyl-2-methane (BHPM), and further metabolised in the liver to a glucuronide salt. Excretion: Via urine, bile (as BHPM). Elimination half-life: Approx 8 hours (BHPM).
Oral: Store between 20-25°C. Protect from humidity. Rectal: Store below 30°C.
A06AB02 - bisacodyl ; Belongs to the class of contact laxatives.
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