Bisoprolol - oral

Patient Medicine Information
Why do I need this medicine?
Bisoprolol helps to keep your blood pressure under control.

It may also be used to manage angina pectoris (chest pain).

This medicine is also used together with other medicines to treat heart failure (weakness and inability of the heart to pump blood).

Bisoprolol may be used to treat other conditions as decided by your doctor.
How do I take this medicine?
Take Bisoprolol exactly as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor.

You may take this medicine with or without food. Try to take it at the same time each day.

Bisoprolol must be taken regularly for it to be effective. Continue taking this medicine even when you feel better. Do not stop taking it suddenly as this may worsen your condition.
What should I do if I have forgotten to take this medicine?
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your normal dosing schedule.

DO NOT double a dose under any circumstances.

If you often forget to take your medicine, let your doctor and pharmacist know.
When should I not use this medicine?
Alert your doctor if you have the following conditions:
  • acute heart failure or worsening heart failure that requires injection of medicines into a vein that can increase the force of contraction of the heart
  • slow heartbeat
  • 2nd- or 3rd-degree heart block (without a pacemaker)
  • sick sinus syndrome (abnormal heart rhythms due to problems with your heart's natural pacemaker)
  • cardiogenic shock (acute serious heart condition causing low blood pressure and circulatory failure)
  • low blood pressure
  • severe asthma or severe lung obstruction
  • severe peripheral arterial occlusive disease (blockage or narrowing of an artery in the legs or the arms)
  • severe Raynaud’s syndrome (poor blood circulation which makes the toes and fingers numb and pale when feeling cold or stressed)
  • untreated phaeochromocytoma (rare tumour of the adrenal gland causing high blood pressure)
  • metabolic acidosis (a condition when there is too much acid in the blood)
as Bisoprolol may not be suitable for you.
What should I take note of while taking this medicine?
Inform your doctor if you have the following conditions:
  • heart problems caused by narrowed heart arteries
  • 1st-degree heart block
  • peripheral arterial occlusive disease (blockage or narrowing of an artery in the legs or the arms)
  • Prinzmetal’s angina (a rare type of chest pain that occurs when a person is at rest)
  • bronchospastic disease (tightening of the muscles that line the airways in your lungs)
  • phaeochromocytoma (rare tumour of the adrenal gland causing high blood pressure)
  • active or previous psoriasis (a type of skin disease that allows the skin cells to rapidly build up causing itchy patches of thick, red skin and silvery scales)
  • excessive thyroid hormones in the blood
  • myasthenia gravis (muscle weakness disorder)
  • history of severe allergic reaction to allergens
  • diabetes
  • liver disease
  • kidney disease
Let your doctor know if you are pregnant or breastfeeding.

If you are going to have an operation, including minor surgery and dental work, inform your doctor or dentist that you are taking this medicine.

Inform your doctor if you will undergo desensitisation therapy e.g. for the prevention of hay fever.

Let your doctor know if you are following a strict fasting schedule.

Why is it important to keep my appointments with the doctor?

Keep your appointments with your doctor. Your doctor needs to monitor your condition and check your response to the medication regularly.
  • Routine monitoring of heart rate, heart rhythm, and blood pressure may be needed while you are being treated with this medicine.
  • Regular monitoring of signs of breathing distress and worsening heart failure may also be needed.
What lifestyle changes can I make to improve my blood pressure?

Regular exercise and eating a healthy diet will help control your blood pressure and improve your overall health. Engage in physical activity like walking for at least 30 to 60 minutes on most days of the week. If you have not exercised for a long time, start with light exercises such as slow walks. Speak to your doctor about what type of exercise would be suitable for you. Follow a healthy diet plan by eating more fruits, vegetables, whole grains and low-fat dairy products and reduce your intake of foods high in saturated fat, cholesterol and sodium. Cutting down on deep-fried foods and using less salt when cooking can kick-start your healthy diet.

If you smoke, you should try to quit. Smoking is harmful to your blood pressure, heart and overall health. Speak to your doctor or pharmacist about ways to stop your smoking habit.
What side effects could I experience?
Bisoprolol may cause any of the following side effects: nausea, vomiting, constipation, diarrhoea, headache, dizziness, tiredness, weakness, low blood pressure, slow heartbeat, and feeling of coldness or numbness in your arms or legs.

Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Can I take this with other medicines?
Inform your doctor and pharmacist if you are taking or using any of these medicines:
  • other medicines for high blood pressure e.g. clonidine, verapamil, methyldopa, nifedipine, amlodipine, moxonidine, rilmenidine, reserpine, guanethidine
  • medicines for heart disease e.g. amiodarone, disopyramide, quinidine, diltiazem, digoxin
  • medicines for diabetes e.g. insulin, glibenclamide, metformin
  • medicine to block pain and other sensations
  • NSAIDs (medicines for pain and inflammation)
  • dobutamine (medicine to treat acute heart failure)
  • isoprenaline (medicine to treat heart block or abnormal heartbeat)
  • epinephrine (emergency medicine to treat severe allergic reactions)
  • norepinephrine (medicine to treat low blood pressure)
  • medicines to treat depression e.g. isocarboxazid, phenelzine, tranylcypromine, amitriptyline, nortriptyline, desipramine, imipramine, doxepin
  • sleep-inducing medicines e.g. amobarbital
  • topical medicines used to treat increased pressure in the eye
  • rifampicin (medicine for lung infection known as tuberculosis)
  • mefloquine (medicine to treat malaria)
  • moxisylyte (medicine to treat Raynaud’s disease, poor blood circulation which makes the toes and fingers numb and pale when feeling cold or stressed)
This list does not include all medicines that may interact with Bisoprolol.

Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicine, supplements and medicines that you buy without a prescription.
What special dietary instructions should I follow?
Avoid alcohol.

Cut down on your salt intake. This may help lower your blood pressure and improve your overall health. Discuss with your doctor or dietitian about ways to cut down on your salt intake.
How should I store this medicine?
Store in a cool, dry place away from the reach of children.

Protect from moisture.

Medicines must not be used past the expiry date.
This information is independently developed by MIMS based on bisoprolol - oral and is provided for your reference only. It is not a replacement for and should only be used in conjunction with full consultation with a licensed healthcare professional, the information provided by your pharmacist and/or the manufacturer of the medication. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, we shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2022 MIMS. All rights reserved. Powered by
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