Bizan Special Precautions



Full Prescribing Info
Special Precautions
Serious and occasionally fatal hypersensitivity (anaphylactic) reactions have occurred in patient receiving beta-lactam antibiotics. Before therapy with Doripenem is started, careful inquiry should be made concerning a previous history of hypersensitivity reactions to other active substance in this class or to beta-lactam antibiotics. Doripenem should be used with caution in patients with such a history. Should a hypersensitivity reaction to doripenem occur, it should be discontinued immediately and appropriate measures taken. Serious acute hypersensitivity (anaphylactic) reactions require immediate emergency treatment.
Seizures have infrequently been reported during treatment with other carbapenems.
Pseudomembranous colitis due to Clostridium difficile has been reported with Doripenem as with nearly all anti-bacterial agents and may range in severity from mild to life-threatening. Therefore, it is important to consider this diagnosis in patients who present with diarrhoea during or subsequent to the administration of Doripenem (see Adverse Reactions).
Administration of Doripenem, like other antibiotics, has been associated with emergence and selection of strains with reduced susceptibility. Patients should be carefully monitored during therapy. If superinfection occur, appropriate measures should be taken. Prolonged use of doripenem should be avoided.
When Doripenem was used investigationally via inhalation, pneumonitis occurred. Therefore, doripenem should not be administered by this route.
Effects on Ability to Drive and Use Machines: No studies on the effects of Doripenem on the ability to drive and use machines have been performed. Based on reported adverse drug reaction, it is not anticipated that doripenem will affect the ability to drive and use machines.
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