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Indications and Dosage
Oral
Mucolytic Adult: As tab/solution: 8-16 mg tid.
Child: As tab/solution: 2-5 years 4 mg bid; 6-11 years 8 mg tid; ≥12 years Same as adult dose. |
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Administration
May be taken with or without food.
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Special Precautions
Patient with history of peptic ulcer disease, asthma. Severe renal and hepatic impairment. Treatment with a cough medicine in children (especially under 6 years old) should be considered carefully due to potential risks and limited evidence on efficacy. Pregnancy and lactation.
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Adverse Reactions
Significant: Rarely, Stevens-Johnson syndrome and toxic epidermal necrolysis (TEN).
Gastrointestinal disorders: Nausea, vomiting, diarrhoea, upper abdominal pain. General disorders and administration site conditions: Sweating. Immune system disorders: Angioedema, urticaria, bronchospasm. Nervous system disorders: Headache, dizziness. Skin and subcutaneous tissue disorders: Rash, pruritus. |
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Action
Description: Bromhexine enhances mucus transport by reducing mucus viscosity and by activating the ciliated epithelium (mucociliary clearance). This secretolytic and secretomotor effect in the bronchial tract area relieves cough and facilitates expectoration.
Pharmacokinetics: Absorption: Rapidly and completely absorbed from the gastrointestinal tract. Bioavailability: Approx 20%. Time to peak plasma concentration: Approx 1 hour. Distribution: Widely distributed to body tissues. Crosses blood brain-barrier and placenta (small amounts). Plasma protein binding: Approx 95%. Metabolism: Undergoes extensive hepatic 1st-pass metabolism. Excretion: Via urine (approx 85-90%, mainly as metabolites). Terminal elimination half-life: 13-40 hours. |
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Chemical Structure
 Source: National Center for Biotechnology Information. PubChem Database. Bromhexine, CID=2442, https://pubchem.ncbi.nlm.nih.gov/compound/Bromhexine (accessed on Jan. 21, 2020) |
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Storage
Store below 25°C.
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MIMS Class
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ATC Classification
R05CB02 - bromhexine ; Belongs to the class of mucolytics. Used in the treatment of wet cough.
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References
Anon. Bromhexine. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 02/08/2018. Boehringer Ingelheim NZ Ltd. Bisolvon Chesty Forte Tablets, Oral Solution data sheet 20 September 2017. Medsafe. http://www.medsafe.govt.nz/. Accessed 02/08/2018. Buckingham R (ed). Bromhexine. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 02/08/2018.
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