Generic Medicine Info
Indications and Dosage
Prophylaxis of motion sickness
Adult: For the prevention of nausea, vomiting, and dizziness associated with motion sickness: 25-50 mg as a single dose prior to travelling; may give further doses as needed. Max: 100 mg daily. Dosage recommendations may vary among countries and individual products (refer to detailed product guidelines).

Allergic conditions, Nausea and vomiting
Adult: 25-50 mg as a single dose; may give further doses as needed. Max: 100 mg daily. Dosage recommendations may vary among countries and individual products (refer to detailed product guidelines).
Should be taken with food. Take w/in 30 min before meals.
Pregnancy and lactation.
Special Precautions
Patient with bladder neck obstruction or enlarged prostate, increased eye pressure, gastrointestinal obstruction.
Adverse Reactions
Eye disorders: Blurred vision.
Gastrointestinal disorders: Diarrhoea, dyspepsia, dry mouth.
Nervous system disorders: Drowsiness, dizziness, headache.
Skin and subcutaneous tissue disorders: Maculopapular rash.
Patient Counseling Information
This drug may cause CNS depression, which may impair physical or mental abilities; if affected, do not drive or operate machinery.
Drug Interactions
May enhance the adverse reactions of other CNS depressants.
Food Interaction
May potentiate the CNS depressant effect of alcohol.
Description: Buclizine, a piperazine derivative, is a sedating antihistamine with antiemetic and orexigenic effects. It also exerts minimal central antimuscarinic action.
Chemical Structure

Chemical Structure Image

Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 6729, Buclizine. https://pubchem.ncbi.nlm.nih.gov/compound/Buclizine. Accessed Apr. 27, 2022.

Store between 15-30°C. Protect from moisture and light.
MIMS Class
Antihistamines & Antiallergics
ATC Classification
R06AE01 - buclizine ; Belongs to the class of piperazine derivatives used as systemic antihistamines.
Anon. Buclizine. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 01/03/2022.

Buckingham R (ed). Buclizine Hydrochloride. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 01/03/2022.

Orafene Tablet (Prime Pharmaceutical Sdn. Bhd.). National Pharmaceutical Regulatory Agency - Ministry of Health Malaysia. https://www.npra.gov.my. Accessed 01/03/2022.

Disclaimer: This information is independently developed by MIMS based on Buclizine from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2022 MIMS. All rights reserved. Powered by MIMS.com
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