Non-productive cough
Adult: As 50 mg tab: 2 or 3 tabs daily at intervals of 8 or 12 hours. As 7.5 mg/5 mL syr: 15 mL up to 4 times daily.
Indications and Dosage
Oral
Non-productive cough Adult: As 50 mg tab: 2 or 3 tabs daily at intervals of 8 or 12 hours. As 7.5 mg/5 mL syr: 15 mL up to 4 times daily.
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Contraindications
Children <18 years. 1st trimester of pregnancy.
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Special Precautions
Renal and hepatic impairment. Pregnancy (2nd to 3rd trimester) and lactation.
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Adverse Reactions
Significant: Somnolence, dizziness.
Gastrointestinal disorders: Diarrhoea, nausea. Skin and subcutaneous tissue disorders: Urticaria, rash. |
Patient Counseling Information
This drug may cause dizziness and somnolence, if affected, do not drive or operate machinery.
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Overdosage
Symptoms: Drowsiness, dizziness, nausea, vomiting, diarrhoea, hypotension. Management: Symptomatic treatment. Administer activated charcoal or saline laxative, or perform gastric lavage. Monitor vital functions.
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Drug Interactions
Concomitant use of expectorants may lead to retention of mucous in the respiratory system, which can increase the risk of bronchospasm and airway infection.
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Action
Description: Butamirate is a non-narcotic antitussive which presents nonspecific anticholinergic and antispasmodic effect, facilitating respiration. It acts centrally by diminishing the tussigenic reflex, and peripherally via a bronchospasmolytic activity enhanced by an anti-inflammatory action.
Pharmacokinetics: Absorption: Rapidly and completely absorbed from the gastrointestinal tract. Time to peak plasma concentration: Approx 1.5 hours. Distribution: Plasma protein binding: Approx 95% Metabolism: Undergoes hydrolysis to phenyl-2-butyric acid and diethylaminoethoxyethanol. Excretion: Primarily via kidneys as metabolites. Plasma elimination half-life: Approx 13 hours. |
Storage
Store below 30°C. Protect from light.
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MIMS Class
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ATC Classification
R05DB13 - butamirate ; Belongs to the class of other cough suppressants.
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References
Buckingham R (ed). Butamirate Citrate. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 07/08/2018. Butamirate 7.5 mg/5 mL Syrup (Actavis Group PTC ehf). MHRA. https://products.mhra.gov.uk/. Accessed 07/08/2018. Sinecod Forte (Novartis Healthcare). MIMS Philippines. https://www.mims.com/philippines. Accessed 12/11/2015.
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