Should be used with caution in patients with severe hypertension and cardiac insufficiency.
Prolonged use may produce subcapsular cataracts, glaucoma and may enhance the establishment of infections due to fungi or viruses.
In long-term treatment, ophthalmological control should be carried out every 3 months.
Diabetic patients under treatment with Methylprednisolone must be re-examined for their blood and urine sugar values.
Like other glucocorticoids, Methylprednisolone may mask signs of infection.
After prolonged treatment, Methylprednisolone must not be discontinued abruptly, but gradually.
In patients with stressful situation, dosage can be increased.
In patients given corticosteroid should not receive smallpox vaccination or other kind of vaccination, particularly high-dose vaccine to prevent neurological complication possibility.
Prolonged used in children should be with caution because this drug may inhibit their growth and development.
The use in patients with TBC-laten or tuberculin reactivity must be monitored carefully, because of the risk of reactivation.
The effect of glucocorticoids may be potentiated in patients with hypothyroid or hepatic cirrhosis.
This drug should be used during pregnancy only if clearly needed.
Not recommended for pregnant women and nursing mothers.