Camelon 8

Camelon 8

methylprednisolone

Manufacturer:

Caprifarmindo

Marketer:

Caprifarmindo
Full Prescribing Info
Contents
Methylprednisolone.
Description
Each tablet contains: Methylprednisolone 8 mg.
Action
Pharmacology: Methylprednisolone, a semisynthetic derivative of the natural renal cortex hormone, cortisol.
Methylprednisolone has glucocorticoid actions.
In common with other glucocorticoids, Methylprednisolone influences the metabolism in almost all tissues. These effects are vital to maintain the body's homeostasis and to regulate the activities of the immune system.
Indications/Uses
CAMELON is indicated for the treatment in the conditions include: bronchial asthma (usually where other drugs, e.g. sympathomimetics or theophylline, fail to produce the desired result or there is marked bronchial hypersensitivity), allergic rhinitis, urticaria, eczema or dermatitis, acute rheumatic fever, rheumatoid arthritis, acquired (autoimmune) hemolytic anemia, idiopathic thrombocytopenic purpura in adults, myeloblastosis, lymphogranulomatosis, ulcerative colitis, nephrotic syndrome, skin diseases, lupus erythematosus, dermatomyositis.
CAMELON may also be used for suppression of the immune response after transplantations, as an adjuvant in treatment with cytostatic agents or in radiotherapy, for substitution in primary adrenocortical insufficiency and after adrenalectomy.
Dosage/Direction for Use
Treatment is initiated with comparatively high doses that are reduced in the further course of treatment until a satisfactory result has been reached.
Subsequent to successful initiation of treatment, the daily dose is reduced gradually until the minimum dose required for maintenance.
Treatment for children should be limited to the minimum dosage for the shortest possible time.
Initial doses: Adults : 4 - 80 mg daily.
Children: 0.8 -1.1 mg/kg body weight.
Maintenance doses: Adults : 4 - 8 mg daily, the dosage may be increased up to 16 mg daily.
Children: 2 - 4 mg daily, the dosage may be increased up to 8 mg daily.
Substitution doses: 4 - 8 mg (in Addison's disease, as an adjuvant to mineralocorticoid therapy), in stressful situation, up to16 mg daily.
In hypothyroid patients or patients with hepatic cirrhosis comparatively low doses may be sufficient and a general dose reduction may be necessary.
Treatment must only be interrupted or stopped on medical advice.
After prolonged treatment, particularly with comparatively high doses, CAMELON must not be discontinued abruptly, but gradually.
The entire daily dose should be taken early in the morning with sufficient amounts of liquid, during or immediately after a meal.
In the event of shock or other peracute situations, glucocorticoids must be administered intravenously.
Contraindications
Hypersensitivity to Methylprednisolone or other glucocorticoids.
Gastric ulcers, osteoporosis, psychiatric disorders, amebiasis, systemic mycosis infection, poliomyelitis, narrow or open-angle glaucoma and viral diseases.
Special Precautions
Should be used with caution in patients with severe hypertension and cardiac insufficiency.
Prolonged use may produce subcapsular cataracts, glaucoma and may enhance the establishment of infections due to fungi or viruses.
In long-term treatment, ophthalmological control should be carried out every 3 months.
Diabetic patients under treatment with Methylprednisolone must be re-examined for their blood and urine sugar values.
Like other glucocorticoids, Methylprednisolone may mask signs of infection.
After prolonged treatment, Methylprednisolone must not be discontinued abruptly, but gradually.
In patients with stressful situation, dosage can be increased.
In patients given corticosteroid should not receive smallpox vaccination or other kind of vaccination, particularly high-dose vaccine to prevent neurological complication possibility.
Prolonged used in children should be with caution because this drug may inhibit their growth and development.
The use in patients with TBC-laten or tuberculin reactivity must be monitored carefully, because of the risk of reactivation.
The effect of glucocorticoids may be potentiated in patients with hypothyroid or hepatic cirrhosis.
This drug should be used during pregnancy only if clearly needed.
Not recommended for pregnant women and nursing mothers.
Use In Pregnancy & Lactation
This drug should be used during pregnancy only if clearly needed.
Not recommended for pregnant women and nursing mothers.
Adverse Reactions
Depending on the dosage and duration of treatment, glucocorticoids may give rise to the following side effects: moon face, trunk obesity, muscular weakness, hypertension, osteoporosis, reduced glucose tolerance, diabetes mellitus, disorders of sex hormone secretion, peptic ulcer, impairment of antibody response, retarded of growth in children, glaucoma, cataract, thrombosis and pancreatitis.
Central nervous system: headache, vertigo, increased intracranial pressure with papilledema.
Electrolyte disturbance and fluid retention.
Dermatologic and immunologic disturbance.
Drug Interactions
Concomitant administration with cardiac glycosides may potentiate/increase glycoside effect.
Concomitant administration with diuretics may potentiate/increase potassium-depleting effect.
The hypoglycaemic effect on antidiabetic agents and the anticoagulant effect of coumarin derivatives may be reduced by glucocorticoids.
Concomitant administration with Rifampicin, Phenytoin or Barbiturates may reduce corticosteroid effect.
Concomitant administration with Acetosal may potentiate/increase the clearance of chronic high-dose Acetosal.
Convulsions have been reported with concurrent use of Methylprednisolone and Cyclosporin.
Concomitant administration with Ketoconazole and Troleandomycin may inhibit the metabolism of Methylprednisolone and thus, decrease its clearance.
Storage
Store below 30°C.
ATC Classification
H02AB04 - methylprednisolone ; Belongs to the class of glucocorticoids. Used in systemic corticosteroid preparations.
Presentation/Packing
Tab 8 mg x 10 x 10's.
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