Sucrose & food containing sucrose cause abdominal discomfort or even diarrhea. Increased hypoglycemic effect w/ sulphonylurea, metformin or insulin. May affect digoxin bioavailability. Cholestyramine, intestinal adsorbents & digestive enzyme products should be avoided. Concomitant use w/ diuretics (ie, thiazides, furosemides), corticosteroids, phenothiazines, thyroid products, estrogens, OCs, phenytoin, nicotinic acid, sympathomimetics & INH may lead to loss of blood glucose control. Concomitant use w/ neomycin may lead to an enhanced reduction of postprandial blood glucose & to an increase in the frequency & severity of GI adverse reactions.