Cardura

Cardura

doxazosin

Manufacturer:

Pfizer
Concise Prescribing Info
Contents
Doxazosin mesylate
Indications/Uses
HTN & can be used as the initial agent to control BP in the majority of patients. May be used in combination w/ another agent eg, thiazide diuretic, β-blocker, Ca antagonist or an ACE inhibitor in patients not adequately controlled on a single antihypertensive agent. Clinical symptoms in BPH & for reduced urinary flow associated w/ BPH. May be used in BPH patients who are either hypertensive or normotensive.
Dosage/Direction for Use
HTN 1-16 mg daily. Initially 1 mg once daily for 1-2 wk. May be increased to 2 mg once daily for an additional 1-2 wk. If necessary, daily dosage should then be increased gradually at similar intervals to 4, 8 & 16 mg as determined by patient response to achieve desired reduction in BP. Usual dose: 2-4 mg once daily. BPH Initially 1 mg once daily. Depending on individual patient’s urodynamics & BPH symptomatology, dosage may then be increased to 2 mg & thereafter to 4 mg & up to max dose of 8 mg. Recommended titration interval: 1-2 wk. Usual dose: 2-4 mg once daily.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity to doxazosin & quinazolines.
Special Precautions
Postural hypotension/syncope. May lead to symptomatic hypotension w/ concomitant use w/ PDE-5 inhibitors. Intraoperative floppy iris syndrome (IFIS). Inform ophth surgeon in advance of surgery for current or past use of α-blockers. Priapism. Prolonged erections & priapism. May impair ability to drive or operate machinery. Impaired hepatic function. Pregnancy & lactation. Childn.
Adverse Reactions
Vertigo; nausea; edema, asthenia, fatigue, malaise; dizziness, headache, postural dizziness, somnolence, syncope; rhinitis. Leukopenia, thrombocytopenia; tinnitus; blurred vision, IFIS; abdominal pain, constipation, diarrhea, dyspepsia, flatulence, dry mouth, vomiting; pain; cholestasis, hepatitis, jaundice; allergic reaction; abnormal liver function tests, increased wt; anorexia; arthralgia, back pain, muscle cramps & weakness, myalgia; hypoesthesia, paresthesia, tremor; agitation, anxiety, depression, insomnia, nervousness; dysuria, hematuria, micturition disorder & frequency, nocturia, polyuria, urinary incontinence; gynecomastia, impotence, priapism, retrograde ejaculation; aggravated bronchospasm, coughing, dyspnea, epistaxis; alopecia, pruritus, purpura, skin rash, urticaria; hot flushes, hypotension, postural hypotension.
Drug Interactions
PDE-5 inhibitors. Strong CYP3A4 inhibitors eg, clarithromycin, indinavir, itraconazole, ketoconazole, nefazodone, nelfinavir, ritonavir, saquinavir, telithromycin or voriconazole. Increased mean AUC w/ cimetidine.
MIMS Class
Other Antihypertensives / Drugs for Bladder & Prostate Disorders
ATC Classification
C02CA04 - doxazosin ; Belongs to the class of alpha-adrenoreceptor antagonists, peripherally-acting antiadrenergic agents. Used in the treatment of hypertension.
Presentation/Packing
Form
Cardura tab 1 mg
Packing/Price
5 × 10's (Rp602,502/boks)
Form
Cardura tab 2 mg
Packing/Price
5 × 10's (Rp991,507/boks)
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