Carvilol Drug Interactions





Full Prescribing Info
Drug Interactions
When CARVEDILOL is used at the same time as other drugs, the following must be taken into account: The effect of other blood - pressure - lowering drugs may be intensified.
Simultaneous therapy with reserpine, guanethidine, methyldopa, clonidine or guanfacine may cause and intensified blood - pressure and heart - rate lowering effect.
Rifampicin reduces the systemic availability of carvedilol and thus, possibly its blood pressure lowering action.
Concomitant administration of clonidine with agents with β-blocking properties may potentiate blood pressure and heart rate lowering effect. When concomitant treatment with carvedilol and clonidine is to be terminated, carvedilol should be discontinued first. Clonidine therapy can then be discontinued several days later by gradually decreasing the dosage.
When nifedipine and carvedilol are used simultaneously there may be a more abrupt drop in blood pressure. When calcium channel blockers of the verapamil or diltiazem type of other anti-arrhythmic drugs are used simultaneously, careful monitoring of blood pressure and ECG are indicated since there may be a sharp drop on blood pressure, a reduced heart rate (bradycardia) or other rhythm disturbances of the heart. Calcium channel blockers and anti-arrhythmic drugs should therefore, not be administered intravenously during treatment with carvedilol.
When carvedilol and anesthesia drugs are used simultaneously, attention must be paid to the decreasing in heart rate, the cardiac effects (negative inotropism) of the two drugs, and stimulus conductions in the heart may be delayed. If patient is required to undergo anesthesia, please inform the doctor that patient is taking carvedilol.
Carvedilol can cause clinically relevant elevation of plasma digoxin concentrations.
The effects of insulin or oral blood-sugar-lowering drugs may be intensified. The signs of low blood sugar (hypoglycaemia) may be masked or attenuated (especially the increase in heart rate). Regular monitoring of blood sugar is therefore required with diabetics. Certain sedative (barbiturates, phenothiazines) and drugs for treating depression (cyclic anti-depressants) vasodilating drugs and alcohol may intensify the blood pressure lowering effect.
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