Certican

Certican

everolimus

Manufacturer:

Novartis Indonesia
Concise Prescribing Info
Contents
Everolimus
Indications/Uses
In combination w/ ciclosporin for microemulsion & corticosteroids for the prophylaxis of organ rejection in adult patients at a low to moderate immunological risk receiving allogenic renal or cardiac transplant.
Dosage/Direction for Use
Initially 0.75 mg twice daily. Daily dose should always be given in 2 divided doses.
Administration
May be taken with or without food: Take consistently either always w/ or always w/o meals. Swallow whole, do not chew/crush. Avoid grapefruit juice.
Contraindications
Rare hereditary problems of galactose intolerance, severe lactase deficiency or glucose-galactose malabsorption. Pregnancy & lactation.
Special Precautions
Patients at high immunological risk; hepatic impairment. Avoid exposure to sunlight & UV light. Hyperlipidemia/severe refractory hyperlipidemia. Patients under HMG-CoA reductase inhibitor treatment.
Adverse Reactions
Infections, sepsis, leucopenia, thrombocytopenia, anemia, coagulopathy, thrombotic thrombocytopenic purpura/hemolytic uremic syndrome, hypercholesterolemia, hyperlipidemia, hypertriglyceridemia, HTN, lymphocele, venous thromboembolism, pneumonia, abdominal pain, diarrhea, nausea, pancreatitis, vomiting, angioneurotic edema, acne, surgical wound complication, UTI, edema, pain, angioedema (tongue & pharynx).
Drug Interactions
CYP3A4 inhibitors &/or inducers, CYP2D6 substrates w/ narrow therapeutic index, PgP inhibitors, rifampicin, ACE inhibitors, grapefruit juice & live vaccines.
MIMS Class
ATC Classification
L04AA18 - everolimus ; Belongs to the class of selective immunosuppressive agents. Used to induce immunosuppression.
Presentation/Packing
Form
Certican tab 0.5 mg
Packing/Price
6 × 10's (Rp2,012,905/boks)
Form
Certican tab 0.25 mg
Packing/Price
6 × 10's (Rp1,102,950/boks)
Form
Certican tab 0.75 mg
Packing/Price
6 × 10's (Rp3,108,300/boks)
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