Cetrimide


Generic Medicine Info
Indications and Dosage
Topical/Cutaneous
Dandruff, Scalp psoriasis, Seborrhoeic dermatitis
Adult: As 10% liq, in combination w/ undecenoic acid: Apply 1/2 to 1 teaspoonful 3 times during 1st wk, then twice wkly thereafter to the wetted scalp or hair. For application to other areas, apply sufficient amount as required and allow to remain in contact for 2 min.
Child: Same as adult dose.

Topical/Cutaneous
Superficial burns, Wound cleansing
Adult: As 0.5% cream: Apply directly to affected area. As 0.5% spray: Spray onto affected area from a distance of 2-4 inches bid or tid.
Child: Same as adult dose.
Incompatibility
Incompatible w/ anionic surfactants (e.g. soaps), bentonite, iodine, phenylmercuric nitrate, alkali hydroxides.
Contraindications
Hypersensitivity.
Adverse Reactions
Skin irritation and sensitisation. Rarely, burns (w/ concentrated soln).
Patient Counseling Information
Avoid application to the eyes, body cavities, and badly inflamed skin.
Drug Interactions
Enhanced bactericidal activity w/ preparations containing alcohol.
Action
Description: Cetrimide is a quaternary ammonium compound similar to cationic surfactants w/ bactericidal activity against gm+ve and some gm-ve bacteria. It dissociates in aqueous soln into a smaller inactive anion and a relatively large and complex cation that is responsible for the surface activity.
Chemical Structure

Chemical Structure Image
Cetrimide

Source: National Center for Biotechnology Information. PubChem Database. Cetrimide, CID=14250, https://pubchem.ncbi.nlm.nih.gov/compound/Cetrimide (accessed on Jan. 21, 2020)

Storage
Store between 5-30°C.
ATC Classification
D08AJ04 - cetrimide ; Belongs to the class of quaternary ammonium compound antiseptics. Used in the treatment of dermatological diseases.
D11AC01 - cetrimide ; Belongs to the class of medicated shampoos.
References
Buckingham R (ed). Cetrimide. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 01/12/2016.

Joint Formulary Committee. Cetrimide with Undecenoic Acid. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 01/12/2016.

Disclaimer: This information is independently developed by MIMS based on Cetrimide from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 MIMS. All rights reserved. Powered by MIMS.com
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