Clotiapine


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult : PO Anxiety; Mania; Schizophrenia 10-200 mg/day in divided doses, up to 360 mg/day for severe psychoses.
Dosage Details
Oral
Anxiety, Mania, Schizophrenia
Adult: 10-200 mg daily in divided doses. Up to 360 mg/day in severe or resistant psychoses.
Contraindications
Coma; severe CNS depression, pheochromocytoma.
Special Precautions
Hepatic or renal impairment; history of jaundice; CV disease; angle-closure glaucoma; diabetes mellitus; hyperthyroidism; Parkinson's disease; epilepsy and post-encephalitic state, depression, myasthenia gravis; prostatic hypertrophy; severe resp disease; blood dyscrasias. May precipitate coma, affect driving. Pregnancy; lactation; elderly.
Adverse Reactions
Alter temp regulation; neuroleptic malignant syndrome; CNS effects (extrapyramidal effects); GI disturbances; nasal congestion; antimuscurinic symptoms; CV symptoms, ECG changes; endocrine effects; blood dyscrasias; photosensitisation, contact sensitisation, rashes; jaundice; corneal and lens opacities; purplish pigmentation of skin and eye.
Drug Interactions
CNS depressants eg, alcohol, anticholinergics, antihypertensives, α/β-blocker, lithium, trazodone, valproic acid, chloroquine, tricyclic antidepressants, antiarrhythmics, cisapride, pimozide, sparfloxacin, metoclopramide, amiodarone, cimetidine, delavirdine, fluoxetine, paroxetine, propafenone, quinidine, ritonavir, sertraline, barbiturates, levodopa, guanethidine, guanadrel, smoking.
Action
Description: Clotiapine is a short-acting dibenzothiazepine antipsychotic with general properties similar to those of phenothiazines.
MIMS Class
Disclaimer: This information is independently developed by MIMS based on Clotiapine from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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