Pharmacology: Betamethasone is a synthetic glucocorticoid with an anti-inflammatory and immunosuppressant effect. Its use for adrenocortical insufficiency should be combined with a mineralocorticosteroid since its natrium effect (mineralocorticosteroid nature) is very low.
The anti-inflammatory effect consists of stabilizing lysosomal leucocyte, preventing acid-destructing hydrolase release from leucocyte, preventing macrophage accumulation on inflammation site, decreasing leucocyte adherence capacity on endothelium capillary, decreasing capillary wall permeability and edema, bearing against histamine activity kinin release from substrate, decreasing fibroblast proliferation, precipitating collagen and other mechanisms. Duration of anti-inflammatory activity is in line with duration of hypothalamic-pituitary-adrenal (HPA) axis pressing. Colergis can decrease lymphatic activity and volume, produce lymphocytopenia, decrease antigen-antibody interaction tissue reactivity immunology concentration in such a way that suppresses immune response.
Betamethasone also stimulates erythroid cells in bone marrow, elongating erythrocyte and blood platelet lifespan, bringing on neutrophilia and eosinopenia, increasing protein catabolism, gluconeogenesis and lipid redistribution from peripheral to central part of the body, as well as decreasing intestinal absorption and increasing renal excretion of calcium.
Dexchlorpheniramine maleate is a propylamine derivative antihistamine. Dexchlorpheniramine competitively inhibits histamine pharmacologic action (receptor H1 histamine antagonist).