Concor

Concor

bisoprolol

Manufacturer:

PT. Merck Tbk
Concise Prescribing Info
Contents
Bisoprolol hemifumarate
Indications/Uses
Stable chronic moderate to severe heart failure w/ reduced systolic ventricular function in addition to ACE inhibitors, & diuretics & cardiac glycosides (optional). HTN & angina pectoris.
Dosage/Direction for Use
1 tab (Concor 5) daily in the morning. Usual dose range: 5-10 mg daily; some patients may require up to 20 mg daily. Stable CHF Initially 1.25 mg once daily in 1st wk & titrate dose in stepwise increments. Maintenance: 10 mg once daily.
Administration
May be taken with or without food: Swallow whole, do not chew/crush.
Contraindications
Acute heart failure or during episodes of heart failure decompensation requiring IV inotropic therapy, cardiogenic shock, 2nd or 3rd degree AV block, sick sinus syndrome, SA block, bradycardia (<60 bpm), hypotension (systolic BP <100 mmHg), severe bronchial asthma or severe COPD, late stages of peripheral arterial occlusive disease & Raynaud's syndrome, untreated phaeochromocytoma, metabolic acidosis.
Special Precautions
Bronchospasm, concomitant treatment w/ inhalational anesth, DM w/ large fluctuations in blood glucose values, strict fasting, ongoing desensitization therapy, 1st degree AV block, Prinzmetal's angina, peripheral arterial occlusive disease, psoriasis. May mask symptoms of thyrotoxicosis.
Adverse Reactions
Cardiac failure, dyspnea, dizziness, cardiomyopathy, bradycardia, fatigue, viral infection, pneumonia. Feeling of coldness or numbness in the extremities, nausea, vomiting, diarrhea, constipation. Tiredness, exhaustion, dizziness, headache (occur at start of treatment but usually disappear after 1-2 wk).
Drug Interactions
Class I antiarrhythmics, non-dihydropyrdine (eg, verapamil & diltiazem) & dihydropyridine (eg, felodipine & amlodipine) Ca antagonists, centrally acting antihypertensives (eg, clonidine, methyldopa, monoxonide, rimenidine), parasympathomimetics, other β-blockers (including eye drops), insulin & oral antidiabetic drugs, anaesth agents, digitalis glycosides, NSAIDs, β- & non-selective (eg, noradrenalin, adrenaline) sympathomimetics, TCAs, barbiturates, phenothiazines, other antihypertensive agents, mefloquine, MAOIs (except MAO-B inhibitors), ergotamine derivatives, rifampicin.
MIMS Class
ATC Classification
C07AB07 - bisoprolol ; Belongs to the class of selective beta-blocking agents. Used in the treatment of cardiovascular diseases.
Presentation/Packing
Form
Concor FC tab 5 mg
Packing/Price
100's (Rp782,242/pak)
Form
Concor FC tab 1.25 mg
Packing/Price
50's (Rp171,402/pak)
Form
Concor FC tab 10 mg
Packing/Price
3 × 10's (Rp335,948/boks)
Form
Concor FC tab 2.5 mg
Packing/Price
100's (Rp539,916/pak)
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