Coxtor

Coxtor

etoricoxib

Manufacturer:

Amarox
Concise Prescribing Info
Contents
Etoricoxib
Indications/Uses
Symptomatic relief of OA, RA, ankylosing spondylitis, pain & signs of inflammation associated w/ acute gouty arthritis; chronic musculoskeletal pain, acute pain associated w/ dental surgery.
Dosage/Direction for Use
OA & chronic musculoskeletal pain 60 mg once daily. RA, post-op dental pain, ankylosing spondylitis 90 mg once daily. Duration of treatment for ankylosing spondylitis: Not >1 yr. Acute gouty arthritis 120 mg once daily. Max: 8 days. Mild hepatic insufficiency (Child-Pugh score 5-6) 60 mg once daily.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity. CHF (NYHA II-IV), established ischemic heart disease, peripheral arterial disease &/or cerebrovascular disease (including patients who have recently undergone CABG surgery or angioplasty).
Special Precautions
Serious hypersensitivity reactions (eg, anaphylaxis & angioedema) w/in the 1st mth of treatment. Discontinue use at 1st appearance of skin rash, mucosal lesions, or any other sign of hypersensitivity. Patients w/ known CV disease or risk factors for CV disease; fluid retention or heart failure; previously experienced acute asthmatic attacks, urticaria, or rhinitis. Closely monitor BP during the initiation of NSAID treatment & throughout the course of therapy. Prior history of ulcer disease or GI bleeding. Concomitant use of oral corticosteroids or anticoagulants, longer duration of NSAID therapy, smoking, use of alcohol, older age & poor general health status. Periodically re-evaluate patients need for symptomatic relief & response to therapy. Patients w/ significant risk factors for CV events (eg, HTN, hyperlipidemia, DM, smoking) or peripheral arterial disease. Anti-platelet therapies should not be discontinued. Patients w/ considerable dehydration. Rehydrate patients prior to starting therapy. Consider the possibility of fluid retention, edema or HTN in patients w/ pre-existing edema, HTN, or heart failure. May mask fever, which is a sign of infection. Pre-existing significantly impaired renal function, uncompensated heart failure, or cirrhosis. Not recommended in patients w/ advanced renal disease. Close monitoring of the patient's renal function is advisable. Evaluate for persistently abnormal liver function tests in patients w/ symptoms &/or signs suggesting liver dysfunction, or in whom an abnormal liver function test has occurred. Discontinue if persistently abnormal liver function tests (3x the upper limit of normal) are detected. First 2 trimesters of pregnancy. Avoid in late pregnancy. Lactation. Ped patients. Elderly or debilitated patients.
Adverse Reactions
Asthenia/fatigue, dizziness, lower extremity edema, HTN, dyspepsia, heartburn, nausea, headache, increased ALT & AST. Thrombocytopenia; hypersensitivity reactions including anaphylactic/anaphylactoid reactions eg, shock; hyperkalemia; anxiety, insomnia, confusion, hallucinations, depression, restlessness; dysgeusia, somnolence; blurred vision; CHF, palpitations, angina, arrhythmia; hypertensive crisis; bronchospasm; abdominal pain, oral ulcers, peptic ulcers including perforation & bleeding (mainly in elderly), vomiting diarrhea; hepatitis, jaundice, hepatic failure; angioedema, pruritus, erythema, rash, Stevens-Johnson syndrome, toxic epidermal necrolysis, urticaria, fixed drug eruption; renal insufficiency including renal failure.
Drug Interactions
Increased prothrombin time INR w/ warfarin. Decreased AUC w/ rifampin. May diminish the antihypertensive effect of diuretics, ACE inhibitors & AIIAs. May increase plasma lithium levels. Increased rate of GI ulceration or other complications w/ low-dose aspirin. Increase estrogenic & ethinyl estradiol conc.
ATC Classification
M01AH05 - etoricoxib ; Belongs to the class of non-steroidal antiinflammatory and antirheumatic products, coxibs.
Presentation/Packing
Form
Coxtor FC tab 120 mg
Packing/Price
3 × 10's
Form
Coxtor FC tab 60 mg
Packing/Price
3 × 10's
Form
Coxtor FC tab 90 mg
Packing/Price
3 × 10's
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