Generic Medicine Info
Indications and Dosage
Pernicious or macrocytic anaemia
Adult: 250-1000 mcg, given on alternate days for 1-2 wk, then 250 mcg wkly until the blood count returns to normal. Maintenance doses: 1000 mcg, given every mth.

Megaloblastic anaemia caused by vitamin B12 deficiency
Adult: 50-150 mcg daily.

Pernicious or macrocytic anaemia
Adult: 2,000 mcg daily.
Child: 1,000 mcg daily or every 2 wk.
Renal Impairment
Increased requirement in renal impairment.
Hepatic Impairment
Increased requirement in hepatic impairment.
Should be taken on an empty stomach. Take between meals.
IM/IV/Nasal/Parenteral/SC: C
Description: Cyanocobalamin is vital to growth, hematopoiesis and nucleoprotein and myelin synthesis. As a hematopoietic agent, it is converted to coenzyme B12 needed in the conversion of methylmalonate to succinate and production of methionine from homocysteine, a reaction requiring folate. In the absence of folate, such metabolites cannot be formed and folate deficiency occurs. It is also involved in the maintenance of reduced sulfhydryl (SH) groups which are required by various SH-activated enzyme systems. Through such processes, cyanocobalamin participates in fat and carbohydrate metabolism as well as protein synthesis.
Absorption: Binds to intrinsic factor secreted by gastric mucosa; via the GI tract actively or by passive diffusion.
Distribution: In the blood, bound to transcobalamin II (specific B-globulin carrier protein); distributed and stored in the liver and bone marrow. Crosses the placenta and small amounts enter the breast milk.
Excretion: via bile by enterohepatic recycling; via urine (as unbound B12 and in small fraction).
MIMS Class
Haematopoietic Agents / Vitamin B-Complex / with C
Disclaimer: This information is independently developed by MIMS based on Cyanocobalamin from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2022 MIMS. All rights reserved. Powered by
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