Cyclophosphamide - oral

Patient Medicine Information
Why do I need this medicine?
Cyclophosphamide is used on its own or together with other medicines to treat certain types of cancer.

This medicine may also be used to treat other conditions as decided by your doctor.
How do I take this medicine?
Take Cyclophosphamide exactly as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor.

Take this medicine on an empty stomach, preferably in the morning. You may take it with meals to minimize stomach irritation. Try to take it at the same time each day.

Swallow the tablet or capsule whole with plenty of water. Do not divide, chew or crush the tablet or capsule.

The dose of this medicine will be decided by your doctor. Your doctor will advise you on the treatment timeframe depending on the type and severity of your condition.
What should I do if I have forgotten to take this medicine?
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your normal dosing schedule.

DO NOT double a dose under any circumstances.

If you often forget to take your medicine, let your doctor and pharmacist know.
When should I not use this medicine?
Alert your doctor if you have the following conditions:
  • blood disorder such as low platelet, red or white blood cell count
  • bladder problems such as difficulty in passing urine
as Cyclophosphamide may not be suitable for you.
What should I take note of while taking this medicine?
Inform your doctor if you have the following conditions:
  • diabetes
  • heart disease
  • kidney disease
  • liver disease
  • previous radiation therapy
Let your doctor know if you are pregnant or breastfeeding. If you become pregnant while being treated with Cyclosphosphamide, alert your doctor immediately. This medicine may cause harm to your unborn child. Discuss the use of appropriate birth control methods with your doctor while being treated with Cyclophosphamide.

Wear gloves when handling this medicine to minimise any skin contact. If contact with broken tablets or capsules occurs, wash your hands immediately and thoroughly.

Inform your doctor if you have been recently vaccinated. Do not receive any vaccinations without first asking your doctor.

For as long as you are taking this medicine, you may need to have regular blood tests to check your body’s response to Cyclophosphamide. You may also need to have regular tests for heart, lung, kidney and liver function. Your doctor will advise you about how often you need to have these tests.
What side effects could I experience?
Cyclophosphamide may cause dizziness or blurred vision. If affected, do not drive or take part in any activity in which you need to be alert or to see clearly.

Other side effects may include any of the following: nausea, vomiting, diarrhoea, stomach pain, loss of appetite, hair loss, rashes, skin or nail discolouration, prolonged wound healing, absence of menstrual periods, low sperm count and sterility.

Some side effects may need immediate medical help. Alert your doctor quickly if you experience any of the following:
  • rashes, breathlessness, swollen mouth or eyes
  • chest pain, irregular heartbeat
  • pain or difficulty in passing urine, blood in urine
  • signs and symptoms of liver problems e.g. yellowing of the skin or eyes, stomach pain, tiredness, nausea or vomiting
Cyclophosphamide will cause the level of your red blood cells, white blood cells and platelets to drop.

Red blood cells carry oxygen around your body. A fall in the level of red blood cells may make you feel tired and worn out.

White blood cells help your body to fight infections. A fall in the level of your white blood cells may put you at higher risk for infections, such as coughs, colds and flu, which may lead to more serious infections. Avoid crowded places and people who are sick. Alert your doctor if you have a fever, or a cough or flu that does not go away.

Platelets help your blood to clot when there is a cut in the skin. A fall in the level of your platelets may put you at risk of bleeding more than usual. Do not take part in activities where you may fall or get injured, such as contact sports. Alert your doctor if you get any unusual bruising (large bruises or several bruises, especially if the bruises appeared on their own) or bleeding that takes a long time to stop (for example, too much bleeding when you floss or brush your teeth).

Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Can I take this with other medicines?
Inform your doctor or pharmacist if you are taking any of these medicines:
  • other medicines used to treat cancer e.g. busulfan
  • muscle relaxants e.g. suxamethonium
  • blood-thinning medicines e.g. warfarin
  • medicines to treat fungal infections e.g. ketoconazole, fluconazole, itraconazole
  • medicines used to treat HIV infection e.g. ritonavir
  • certain antibiotics e.g. clarithromycin, erythromycin
  • medicines for gout e.g. allopurinol
  • medicines for pain and inflammation e.g. indomethacin
  • medicines for epilepsy (fits or seizures) e.g. phenytoin
This list does not include all medicines that may interact with Cyclophosphamide.

Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicine, supplements and medicines that you buy without a prescription.
What special dietary instructions should I follow?
Avoid alcohol.
How should I store this medicine?
Store in a cool, dry place away from the reach of children.

Medicines must not be used past the expiry date.

As this is a cancer medicine, always return any unused or expired tablets to the clinic, hospital or pharmacy for disposal. Do not throw it away in the household waste.
This information is independently developed by MIMS based on cyclophosphamide - oral and is provided for your reference only. It is not a replacement for and should only be used in conjunction with full consultation with a licensed healthcare professional, the information provided by your pharmacist and/or the manufacturer of the medication. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, we shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 MIMS. All rights reserved. Powered by
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