Debostin

Debostin

atorvastatin

Manufacturer:

Abbott Products
Concise Prescribing Info
Contents
Atorvastatin
Indications/Uses
Adjunctive therapy to reduce cholesterol elevation in adult & childn 10-17 yr. Prevention of CV complications.
Dosage/Direction for Use
Initially 10 mg once daily. Range: 10-80 mg once daily. Primary hypercholesterolemia & combined (mixed) hyperlipidemia 10 mg once daily for 2 wk & up to 4 wk for max response. Homozygous familial hypercholesterolemia 80 mg. Heterozygous familial hypercholesterolemia Childn 10-17 yr Initial dose: 10 mg daily. Max: 20 mg daily. Adjust dose at ≥4 wkly intervals.
Administration
May be taken with or without food: Avoid excessive consumption (>1 L/day) of grapefruit juice.
Contraindications
Hypersensitivity. Active liver disease; contraception. Pregnancy & lactation.
Special Precautions
Perform liver function test before therapy; alcohol consumption; myalgia/myopathy; malaise, fever; rhabdomyolysis; risk to secondary renal failure; CPK level elevation.
Adverse Reactions
Insomnia; headache; paresthesia; peripheral neuropathy; nausea, diarrhea, constipation, flatulence, pancreatitis, vomiting; myalgia, myopathy, myocytis, cramps; asthenia, edema, angioneurotic; hypo- & hyperglycemia, anorexia; hepatitis; alopecia, pruritis, rash; impotence; angina. Childn 10-17 yr: Thrombocytopenia; allergic reaction; wt gain; hypoestecia, amnesia, dizziness, dysgeusia; tinnitus; urticaria; rhabdomyolysis, arthralgia, back pain; chest pain, peripheral edema, malaise; toxic complication & tendon rupture. Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema multiforme.
Drug Interactions
Concomitant use w/ cyclosporine, fibric acid derivative, erythromycin, azole antifungal agent or niacin. CYP3A4 inducers; antacids; antipyrine; colestipol; digoxin; azithromycin; terfenadine; OC; warfarin; amlodipine; PIs; cimetidine; grapefruit juice; ketoconazole; spironolactone.
ATC Classification
C10AA05 - atorvastatin ; Belongs to the class of HMG CoA reductase inhibitors. Used in the treatment of hyperlipidemia.
Presentation/Packing
Form
Debostin FC tab 20 mg
Packing/Price
3 × 10's
Form
Debostin FC tab 10 mg
Packing/Price
3 × 10's
Form
Debostin FC tab 40 mg
Packing/Price
3 × 10's
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