Generic Medicine Info
Indications and Dosage
Labour induction
Adult: 50 units every 30 minutes, reduce to 25 units every 30 minutes when normal contraction rhythm is established. Max: 500 units.

Labour augmentation
Adult: 25 or 50 units if necessary every ½ hr.
Foetal distress, significant cephalopelvic disproportion, unfavorable presentation of the fetus, excess uterine distention; parity >4; elderly multiparae; previous uterine surgery; severe toxemia; amniotic fluid embolism; hypertonic uterine contractions; placenta praevia; cord presentation or prolapse; mechanical obstruction to delivery; predisposition to uterine rupture.
Special Precautions
Borderline cephalopelvic disproportion; patients >35 yr. Monitor fetal heart rate and uterine motility. Do not employ for prolonged periods in resistant uterine inertia, severe preeclampsia, severe CV disorders. Discontinue in case of foetal distress or uterine hyperactivity. Risk of water intoxication (high doses over prolonged period). Restrict fluid intake by mouth.
Adverse Reactions
Postpartum bleeding; neonatal jaundice; water retention; acute transient hypotension with flushing and reflex tachycardia (rapid IV).
Potentially Fatal: Death; anaphylactic reactions; fatal afibrinogenaemia; maternal deaths from severe hypertension and subarachnoid haemorrhage.
Drug Interactions
Prostaglandins, anaesthetics. Vasopressor effects of sympathomimetics may be enhanced.
Description: Demoxytocin is a synthetic analogue of oxytocin that causes uterine contraction. It is used for induction and augmentation of labour.
MIMS Class
Drugs Acting on the Uterus
Disclaimer: This information is independently developed by MIMS based on Demoxytocin from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2022 MIMS. All rights reserved. Powered by
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Sign up for free
Already a member? Sign in