Depakote ER

Depakote ER

valproic acid

Manufacturer:

Abbott Products
Concise Prescribing Info
Contents
Divalproex Na
Indications/Uses
Acute manic or mixed episodes associated w/ bipolar disorder w/ or w/o psychosis. Mono- & adjunctive therapy of complex partial seizures that occur either in isolation or in association w/ other seizure types & multiple seizure types including absence seizures. Migraine prophylaxis in adults.
Dosage/Direction for Use
Initially 15 mg/kg/day increasing at 1-wk interval by 5-10 mg/kg/day until seizures are controlled or side effects preclude further increases. Max: 60 mg/kg/day.
Administration
Should be taken with food: Swallow whole, do not chew/crush.
Contraindications
Hepatic disease or significant dysfunction. Known urea cycle disorders.
Special Precautions
History of hepatic disease, pancreatitis, decreased food or fluid intake, excessive somnolence; patients on multiple anticonvulsants; organic brain disease. Pregnancy. Childn <2 yr or w/ congenital metabolic disorders or severe seizures accompanied by mental retardation.
Adverse Reactions
Nausea, vomiting, indigestion, diarrhea, abdominal cramps, anorexia; sedation, headache, nystagmus, dizziness, erythema multiforme, skin rash, weakness.
Drug Interactions
Antiepileptics, CNS depressants, aspirin, barbiturates, warfarin, dicumarol.
MIMS Class
ATC Classification
N03AG01 - valproic acid ; Belongs to the class of fatty acid derivatives antiepileptic.
Presentation/Packing
Form
Depakote ER tab 250 mg
Packing/Price
100's (Rp435,435/pak)
Form
Depakote ER tab 500 mg
Packing/Price
100's (Rp870,898/pak)
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