Dexaflox

Dexaflox

pefloxacin

Manufacturer:

Dexa Medica
Full Prescribing Info
Contents
Pefloxacin.
Description
Pefloxacin is 1-ethyl-6-fluoro-7-(4-methyl-1-piperazinyl) 4-oxo-1,4-dihydro 3-quinoline carboxylic acid, a synthetic antibiotic which belongs to quinolone derivatives.
Action
Pharmacology: The mechanism of action of pefloxacin is inhibiting the activity of bacterial DNA gyrase, also influence the bacterial RNA and protein biosynthesis.
Indications/Uses
Variety of severe infections, especially due to gram-negative bacteria and Staphylococcus eg, lower respiratory tract, gastrointestinal, skin and soft tissue, urinary tract and kidney infections, gonorrhea. Dexaflox is not recommended for treatment of other infections which can be managed by the known modest antibiotic agents.
Dosage/Direction for Use
Patients with Normal Liver and Kidney Function: May be given twice daily during meals, each dose is 400 mg (afternoon and evening dose). Initial dose of 800 mg may be given to achieve the effective concentration in the blood rapidly.
Contraindications
Patients with hypersensitivity to pefloxacin and other quinolone derivatives. Glucose-6-phosphate dehydrogenase (G6PD) deficiency.
Use in pregnancy & lactation: Not recommended for pregnant and lactating women, as pefloxacin may cross the placenta and excreted into breast milk.
Use in children: Since prolonged use of pefloxacin may inhibit the growth of cartilage, it is not recommended for children <15 years.
Special Precautions
Avoid direct contact with sunlight or UV light during therapy as there are any risk of high sensitivity to the light.
Dexaflox should not be used as first-line treatment for respiratory tract infection before a bacteriological examination is done.
Severe hepatic insufficiency.
Adverse Reactions
Gastrointestinal Tract Disturbances: Nausea, vomiting, abdominal pain.
Central Nervous System Disturbances: Headache, decreased awareness, nervousness.
Hypersensitivity Reactions: Itching, allergy and photosensitivity.
In high dose (1600 mg/day) may cause thrombocytopenia.
Muscle and joint pain.
Drug Interactions
Co-administration of pefloxacin and theophylline may increase the blood level of theophylline and prolong its half-life. If the concomitant use can not be avoided, the dose of theophylline must be reduced and concentration of theophylline in the blood should be monitored.
The absorption of pefloxacin is influenced by aluminium- and magnesium hydroxide-containing antacids, therefore these drugs should be administered at 1-2 hrs interval.
Cimetidine inhibits the metabolism of pefloxacin in the liver, thus it will increase its half-life.
Storage
Store at a temperature below 30°C. Protect from light.
MIMS Class
ATC Classification
J01MA03 - pefloxacin ; Belongs to the class of fluoroquinolones. Used in the systemic treatment of infections.
Presentation/Packing
FC caplet 400 mg x 5 x 6's.
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