Doripenem is a synthetic of carbapenem class which is useful as an antibacterial. Doripenem has bactericidal activity through inhibition of bacterial cell wall biosynthesis. Doripenem activates various important penicillin-binding proteins (PBPs), thereby inhibiting cell wall synthesis and subsequently resulting in cell death.
Doripenem in vitro shows little effect to inhibit or be inhibited by other antibacterials. Weak additives or synergies with amitacin and levofloxacin were seen for Pseudomonas aeruginosa and Gram-positive bacteria with daptomycin, linezolid, levofloxacin, and vancomycin.
For the treatment of infections in adult patients from infections such as nosocomial pneumonia (including pneumonia due to ventilator use). Complicated intra-abdominal infections. Caution should be given to appropriate antibacterial management.
Nosocomial pneumonia (including pneumonia due to ventilator use): 500 mg every 8 hours for 1 or 4 hours. Complicated intra-abdominal infections: 500 mg every 8 hours for 1 hour. The therapy will be given for 5-14 days, depends on the severity of the disease. Patients with renal impairment CrCl 30 - <50 mL/min 250 mg every 8 hours. CrCl <30 mL/min 250 mg every 12 hours.
Symptoms of overdose include hypotension and abnormal walking figure.
Treatment of overdose: Induction by vomiting or gastric lavage.
For seizure by administration of Diazepam injection.
For bradycardia by administration of Atropine.
For arrhythmias by administering Lidocaine.
Hypersensitivity to doripenem and other antibacterial carbapenems. Severe hypersensitivity (e.g anaphylactic reactions, severe skin reactions) to all other types of beta-lactam antibacterials (e.g penicillin or cephalosporin).
Hypersensitivity reaction, seizure, pseudomembranous colitis, superinfection, pneumonitis. Pregnancy & lactation. May affect the ability to drive or operate machine.
Oral candidiasis, vulvomycotic infection; hypersensitivity reaction; headache; phlebitis; nausea, diarrhea, colitis due to C. difficile
; liver enzyme elevation; rash and itches.
Antibacterial carbapenem may reduce serum valproic acid levels. Serum valproic acid levels must be monitored if doripenem is given with valproic acid.
Probenecid competes with doripenem in secretions in the kidney tubules and decreases the clearance of doripenem through the kidneys. It is not recommended to give both of substances concomitantly.
Store in the temperature below 25°C in a tight close container. Keep away from sunlight.
J01DH04 - doripenem ; Belongs to the class of carbapenems. Used in the systemic treatment of infections.