Dulaglutide


Concise Prescribing Info
Indications/Uses
Adjunct to type 2 diabetes mellitus.
Dosage/Direction for Use
Adult : SC Initial: 0.75 mg once weekly, may increase dose up to 1.5 mg once weekly, if glycaemic control is not optimal.
Dosage Details
Subcutaneous
Adjunct to Type 2 diabetes mellitus
Adult: Initially, 0.75 mg once weekly, may increase dose up to 1.5 mg once weekly, if glycaemic control is not optimal. Missed dose: ≤3 days: Administer as soon as possible. >3 days: Skip the missed dose and wait until the next scheduled dose.
Administration
May be taken with or without food.
Contraindications
Personal or family history of medullary thyroid carcinoma (MTC), patient with multiple endocrine neoplasia syndrome type 2 (MEN 2).
Special Precautions
Patient with history of hypersensitivity, pancreatitis, severe gastrointestinal disease (e.g. gastroparesis) and those at risk for developing conduction abnormalities (e.g. ischaemic heart disease, cardiomyopathies). Not intended for the treatment of type 1 diabetes mellitus or diabetic ketoacidosis. Renal and hepatic impairment. Pregnancy and lactation.
Adverse Reactions
Significant: Acute pancreatitis, severe gastroparesis, hypoglycaemia, serious hypersensitivity reactions (e.g. anaphylaxis, angioedema), tachycardia, thyroid tumours.
Gastrointestinal disorders: Nausea, vomiting, diarrhoea, constipation, dyspepsia, flatulence, abdominal pain or discomfort, GERD.
General disorders and administration site conditions: Inj site pain, pruritus, erythema.
Metabolism and nutrition disorders: Decreased appetite.
Nervous system disorders: Fatigue.
Patient Counseling Information
Rotate injection sites within the same body region and use a new needle for each injection. When used in combination with other antidiabetic agents, this drug may cause hypoglycaemia, if affected, do not drive or operate machinery.
MonitoringParameters
Monitor serum glucose, HbA1c, renal function, signs and symptoms of pancreatitis.
Overdosage
Symptoms: Gastrointestinal disorders (e.g. nausea vomiting), hypoglycaemia. Management: Supportive treatment.
Drug Interactions
Increased risk of hypoglycaemia with sulfonylureas or insulin. May delay gastric emptying and reduce the rate of absorption of oral medications.
Action
Description: Dulaglutide is an analogue of glucagon-like peptide-1 (GLP-1), an incretin hormone linked to a modified human Ig G4 fragment and act as GLP-1 receptor agonist. Activation of GLP-1 stimulates insulin release by increasing intracellular cyclic AMP (cAMP) in pancreatic beta cells and suppression of glucagon secretion in a glucose-dependent manner. It also slows gastric emptying thus reduces postprandial glucose (PPG) concentration.
Pharmacokinetics:
Absorption: Absolute bioavailability: 47-65%. Time to peak plasma concentration: Approx 24-72 hours.
Distribution: Volume of distribution: Approx 17-19 L.
Metabolism: Undergoes degradation into amino acids by general protein catabolism pathways.
Excretion: Elimination half-life: Approx 5 days.
Storage
Unopened preparation: Store between 2-8°C. Do not freeze. Protect from light. Once opened: Store below 30°C for up to 14 days.
MIMS Class
ATC Classification
A10BJ05 - dulaglutide ; Belongs to the class of glucagon-like peptide-1 (GLP-1) analogues. Used in the treatment of diabetes.
Disclaimer: This information is independently developed by MIMS based on Dulaglutide from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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