Sucrose & food containing sucrose; sulphonylurea, metformin or insulin. May affect digoxin bioavailability. Cholestyramine, intestinal adsorbents & digestive enzyme products should be avoided. Diuretics, corticosteroids, phenothiazines, thyroid prep, oestrogens, OCs, phenytoin, nicotinic acid, sympathomimetics, Ca-channel blocker & INH tend to produce hyperglycemia & may lead to loss of blood glucose control. Neomycin lead to an enhanced reduction of postprandial blood glucose & to an increase in the frequently & severity of GI adverse reactions.