Local or systemic allergic reactions may occur in hypersensitive individuals. The following side effects have been reported following the administration of vasopressin.
Body as a Whole:
anaphylaxis (cardiac arrest and/or shock) has been observed shortly after injection of vasopressin.
cardiac arrest, circumoral pallor, arrhythmias, decreased cardiac output, angina, myocardial ischemia, peripheral vasoconstriction, and gangrene.
abdominal cramps, nausea, vomiting, passage of gas.
tremor, vertigo, "pounding" in head.
Skin and Appendages:
sweating, urticaria, cutaneous gangrene.
Hypermotility, flatulence, peritonitis, pedal ischemia & subcutaneous infiltration and phlebitis at the infusion site.
The adverse effects of vasopressin are often the pharmacologic effects of the drug.
Severe water retention due to the antidiuretic activity of vasopressin has also been seen.
Catheter dislodgement, bleeding from the catheter site, hematoma at the catheter insertion site, bacteremia, ischemia and local gangrene have occurred in association with intraarterial catheterization.