Fentanyl Dexa Medica

Fentanyl Dexa Medica

fentanyl

Manufacturer:

Dexa Medica
Concise Prescribing Info
Contents
Fentanyl
Indications/Uses
Opioid analgesic supplement in general or regional anaesth. Anaesth premed w/ a neuroleptic agent for induction of anaesth & adjunct in maintenance of general & regional anaesth. Anaesth w/ O2 in selected high-risk patients undergoing major surgery.
Dosage/Direction for Use
Individualized dosage. As analgesic supplement to general anaesth Low dose: 2 mcg/kg. Moderate dose: 2-20 mcg/kg. High dose: 20-50 mcg/kg. Supplemental doses of 25-250 mcg should be tailored to the needs of the patient. As anaesth agent 50-100 mcg/kg. May be increased up to 150 mcg/kg. Ped 2-12 yr 2-3 mcg/kg.
Contraindications
Known intolerance to any of its components or to other opioids.
Special Precautions
Patients should remain under appropriate surveillance for resp depression. Resuscitation equipment & opioid antagonist should be readily available. Induction of muscle rigidity & non-epileptic myoclonic movements can occur. Bradycardia & cardiac arrest can occur if the patient has received insufficient amount of anticholinergic or when combined w/ non-vagolytic muscle relaxants. Appropriate measures to maintain stable arterial pressure should be taken. Avoid use of rapid bolus inj of opioids in patients w/ compromised intracerebral compliance. Patients on chronic opioid therapy or w/ a history of opioid abuse; uncontrolled hypothyroidism; pulmonary disease; decreased resp reserve; alcoholism. Co-administration w/ neuroleptics & drugs that affect the serotonergic neurotransmitter systems eg, SSRIs, SNRIs, MAOIs. Patients w/ COPD, decreased resp reserve & w/ potentially compromised respiration. Consider rapid discontinuation if serotonin syndrome is suspected. May impair ability to drive & use machines. Impaired hepatic or renal function. Not to be used during pregnancy. Breastfeeding is not recommended for 24 hr following administration. Childn <2 yr. Eldery & debilitated patients.
Adverse Reactions
Sedation, dizziness, dyskinesia; visual disturbance; bradycardia, tachycardia, arrhythmia; hypotension, HTN, vein pain; apnea, bronchospasm, laryngospasm; nausea, vomiting; allergic dermatitis; muscle rigidity; post-op confusion, neurological anaesth complication.
Drug Interactions
Barbiturates, benzodiazepines, neuroleptics, general anaesth & other non-selective CNS depressants eg, alcohol may potentiate resp depression of opioids. Decreased clearance w/ CYP3A4 inhibitors. Co-administration w/ SSRIs, SNRIs or MAOIs may increase risk of serotonin syndrome. Increased t½ & reduced plasma clearance of midazolam.
ATC Classification
N01AH01 - fentanyl ; Belongs to the class of opioid anesthetics. Used as general anesthetics.
Presentation/Packing
Form
Fentanyl Dexa Medica inj 50 mcg/mL
Packing/Price
10 mL x 5 × 1's (Rp925,000/boks);2 mL x 5 × 1's (Rp220,000/boks)
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