Patients should remain under appropriate surveillance for resp depression. Resuscitation equipment & opioid antagonist should be readily available. Induction of muscle rigidity & non-epileptic myoclonic movements can occur. Bradycardia & cardiac arrest can occur if the patient has received insufficient amount of anticholinergic or when combined w/ non-vagolytic muscle relaxants. Appropriate measures to maintain arterial BP should be taken. Avoid use of rapid bolus inj in patients w/ compromised intracerebral compliance. Patients w/ uncontrolled hypothyroidism; pulmonary disease; decreased resp reserve; alcoholism. Co-administration w/ neuroleptics & drugs that affect the serotonergic neurotransmitter systems eg, SSRIs, SNRIs, MAOIs. May impair ability to drive & use machines. Impaired hepatic or renal function. Pregnancy & lactation. Childn <2 yr. Eldery & debilitated patients.