Pregnant women and nursing mothers should avoid using Folamil Genio in a dose greater than the suggested dose.
Vitamin D should not be used in those with hypercalcemia and vitamin D toxicity. Supplementary copper should not be used in patients with Wilson's disease (hepatolenticular degeneration), a disease of abnormal copper accumulation, whilst patients with chronic liver and renal failure should exercise extreme caution in the use of copper supplements.
Supplementary calcium should not be used in patients with hypercalcemia (conditions causing hypercalcemia include sarcoidosis, hyperparathyroidism, hypervitaminosis D and cancer).
Supplementary iron should not be used in patients with iron overload, chronic polyarthritis, bronchial asthma, infectious renal complaints in acute phase, uncontrolled hyperparathyroidism, decompensated hepatic cirrhosis, infectious hepatitis and during the 1st trimester of pregnancy.
Beta-carotene should be used with caution in patients with impaired renal or liver function because safe use of Folamil Genio in the presence of these conditions has not been established.
Riboflavin absorption is increased in hypothyroidism and decreased in hyperthyroidism.
Vitamin B12 should not be used in those with Leber's optic atrophy [a congenital disorder associated with chronic cyanide intoxication (eg, from tobacco smoke)]. Decreased levels of vitamin B12 have been associated with reduced ability to detoxify the cyanide in exposed individuals and vitamin B12 may increase the risk of irreversible neurological damage from optic atrophy in those affected with the disorder.