Forbetes XR

Forbetes XR

metformin

Manufacturer:

Sanbe
Concise Prescribing Info
Contents
Metformin HCl
Indications/Uses
Adjunct to diet & exercise or may be used concomitantly w/ sulfonylurea or insulin to improve glycemic control in type 2 DM.
Dosage/Direction for Use
Individualized dosage. Usual starting dose of 500 mg once daily. Max: 2,000 mg. Dose increase should be made in increments of 500 mg wkly.
Administration
Should be taken with food: Take w/ evening meal. Swallow whole, do not chew/crush.
Contraindications
Hypersensitivity. CHF, acute or chronic metabolic acidosis including diabetic ketoacidosis w/ or w/o coma. Patients undergoing radiologic studies involving intravascular administration of iodinated contrast materials. Renal disease or dysfunction eg, serum creatinine level 1.5 mg/dL (male), 1.4 mg/dL (female) or abnormal CrCl which may also result from CV collapse (shock), acute MI & septicemia.
Special Precautions
Suspect lactic acidosis in diabetic patients w/ metabolic acidosis lacking evidence of ketoacidosis eg, ketonuria & ketonemia. Discontinue immediately in patients w/ lactic acidosis; CV collapse (shock), acute CHF, acute MI & other conditions characterized by hypoxemia. Patients w/ serum creatinine level above upper limit of normal for their age should not receive Forbetes XR. Carefully titrate in elderly to establish min effective dose. Monitor renal function before initiation of therapy & at least annually thereafter; regularly in elderly ≥80 yr. Concomitant use w/ cationic drugs eliminated by renal tubular secretion. Temporarily discontinue at the time of or prior to radiologic studies involving use of intravascular iodinated contrast materials or any surgical procedure except minor procedures. Acute or chronic excessive alcohol intake. Patient w/ previously well controlled type 2 DM who develop laboratory abnormalities or clinical illness should be evaluated promptly for evidence of ketoacidosis or lactic acidosis. Hypoglycemia can occur when caloric intake is deficient, strenuous exercise is not compensated by caloric supplementation, or during concomitant use w/ other glucose-lowering agents (eg, sulfonylureas & insulin) or ethanol. A temporary loss of glycemic control may occur during fever, trauma, infection, or surgery. Renal & hepatic impairment. Not recommended for use in pregnancy. Lactation. Childn. Elderly, debilitated, or malnourished patients & w/ adrenal or pituitary insufficiency or alcohol intoxication are particularly susceptible to hypoglycemic effects.
Adverse Reactions
Abdominal pain, constipation, distention abdomen, dyspepsia/heartburn, flatulence; dizziness, headache; upper resp infection; taste disturbance.
Drug Interactions
Enhanced absorption w/ nifedipine. Cationic drugs. Hyperglycemia & may lead to loss of glycemic control w/ thiazide & other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, OCs, phenytoin, nicotinic acid, sympathomimetics, Ca channel blocking drugs, & INH.
MIMS Class
Antidiabetic Agents
ATC Classification
A10BA02 - metformin ; Belongs to the class of biguanides. Used in the treatment of diabetes.
Presentation/Packing
Form
Forbetes XR caplet 500 mg
Packing/Price
10 × 10's (Rp185,000/boks)
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